Results 71 to 80 of about 1,097,154 (336)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

NUTRITION AND ORAL HEALTH IN CHILDREN

open access: yesRomanian Journal of Oral Rehabilitation, 2019
Oral health is integrated into general health and it is essential to well-being and quality of life. Oral and systemic health is conditioned by proper nutrition.
Ancuta Lupu   +9 more
doaj  

Significance of oral health education in maintaining oral health

open access: yesOrapuh Journal, 2021
This article is a qualitative review of the variables that are significant to maintaining oral health through oral health education. The consequences of lack of oral health awareness were also addressed by reviewing the story of a village girl with poor ...
Johnson John Omale   +5 more
doaj  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

CONNECTION BETWEEN ORAL DISEASES AND MENTAL HEALTH

open access: yesRomanian Journal of Oral Rehabilitation
Extensive epidemiological research has been conducted by the World Health Organization (WHO) in recent years to identify and validate associations between mental problems and physical illnesses.
Oana Cristina Cretu   +6 more
doaj   +1 more source

Self-reported Oral Health using WHO's Oral Health Assessment Questionnaire

open access: yesInternational Dental Journal, 2023
Aim or Purpose: To assess the self-reported oral health status and oral health behaviours in patients attending the OPD Materials and Methods: A cross-sectional hospital-based study was conducted on 343 patients attending the OPD.
Dr Mrinalini Singh
doaj  

Quantifying a qualitative framework of patients perceptions, attitudes and behavior relevant to oral health related quality of life [PDF]

open access: yesarXiv, 2017
In a qualitative study, Gregory, Gibson and Robinson proposed a framework of items grouped in seven dimensions reflecting oral health related perceptions, attitudes and behavior to encompass what is relevant when patients assess their own oral health related quality of life (OHRQOL).
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Enhancing Automated Decision Support across Medical and Oral Health Domains with Semantic Web Technologies [PDF]

open access: yesarXiv, 2014
Research has shown that the general health and oral health of an individual are closely related. Accordingly, current practice of isolating the information base of medical and oral health domains can be dangerous and detrimental to the health of the individual. However, technical issues such as heterogeneous data collection and storage formats, limited
arxiv  

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

open access: yesFEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He   +5 more
wiley   +1 more source

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