Results 91 to 100 of about 213,921 (300)

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers : Retrospective cohort study

Sultan Qaboos University Medical Journal, 2016
Objectives: Saliva contains alkaline phosphatase (ALP)—a key intracellular enzyme related to destructive processes and cellular damage—and has buffering capacity (BC) against acids due to the presence of bicarbonate and phosphate ions.
Fatemeh Ahmadi-Motamayel, Parisa Falsafi, Mohammad T. Goodarzi, Jalal Poorolajal   +3 more
doaj   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Efficacy and safety of low-concentration whitestrips for extrinsic tooth discoloration: a randomized controlled trial

Frontiers in Oral Health
ObjectivesThis study aimed to evaluate the effectiveness of Low-concentration Whitestrips with 3% hydrogen peroxide (HP) on extrinsic discoloration of incisors, and to evaluate the safety of whitening process.MethodsEnrolled adults with extrinsic ...
Yuwei Wang, Di Fu, Lin Yao, Yisi Zhong, Ling Zou, Jing He, Wei Yin   +6 more
doaj   +1 more source

Development of Retinal Infarct Due to Intracameral Cefuroxime Injection Following Complicated Cataract Surgery

Türk Oftalmoloji Dergisi, 2018
We present the case of a 60-year-old patient who underwent a complicated cataract surgery with cefuroxime injection (1 mg/0.1 mL) into the anterior chamber at the end of surgery. The patient presented to our hospital due to decrease in visual acuity (VA)
Sabahattin Sül, Aylin Karalezli
doaj   +1 more source

A randomized, double-blind, placebo-controlled, cross-over study to evaluate analgesic activity of Terminalia chebula in healthy human volunteers using a mechanical pain model

Journal of Anaesthesiology Clinical Pharmacology, 2016
Background and Aims: To evaluate analgesic activity and safety of single oral dose (1000 mg) of Terminalia chebula using a mechanical pain model in healthy human volunteers.
Venkata Kishan Pokuri, Chiranjeevi Uday Kumar, Usharani Pingali   +2 more
doaj   +1 more source

Oral transmucosal fentanyl [PDF]

, 1998
None ...
D. Prosser, Friesen, M. Allman, P. Grassby, Streisand   +4 more
core   +1 more source

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Role Of glgC In Cariogenic Potential Of Streptococcus Mutans

International Dental Journal
Aim or purpose: This study investigates the role of the glgC gene in regulating the cariogenic potential of Streptococcus mutans (S. mutans) ATCC 25175. Materials and methods: The S. mutans glgC knockout strain (S.
Lianghang He, Yan Feng
doaj   +1 more source