Results 111 to 120 of about 1,659,411 (286)

Validating nasogastric tube placement with pH testing: A randomized controlled trial protocol

Contemporary Clinical Trials Communications
Background: Enteral nutrition (EN) is preferred when oral feeding is not possible. The use of the Nasogastric Tube (NGT) ensures rapid and low-risk nutrient administration. However, confirming the placement through chest radiography, besides delaying the
Stefano Mancin, Pietro Stallone, Valeria Siro, Manuela Pastore, Daniela Cattani, Diego Lopane, Alessandra Dacomi, Francesco Carlo Tartaglia, Alessandro Bellone, Francesca Serazzi, Georges Laffoucriere, Chiara Coldani, Giuseppina Tomaiuolo, Beatrice Mazzoleni   +13 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Analysis of Salivary pH in Healthy and Diseased Periodontium among Young and Elderly Adults

Journal of Pharmacy and Bioallied Sciences
Introduction: Salivary pH plays a vital role in oral health. Variations in salivary pH influence the progression of periodontal diseases, dental caries, and systemic conditions.
Narenthiran Narasimman, Sayeeganesh Nagarajan, Vignesh Krishnaswamy, Vanathy Desingu, V. M. Deepa, Gayathri Meikandan   +5 more
doaj   +1 more source

Neptune Water Meter Book [PDF]

, 1919
The 1919 Neptune Water Meter Book is a pocket-sized volume bound in leather with gilt edges. It functions as a pocket guide to the Neptune Co. suite of water meter products (Trident-Disk, Trident-Crest, etc.)https://digitalcommons.otterbein.edu ...
Neptune Meter Co.
core  

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Oral pathology and oral medicine in Latin American countries: current stage [PDF]

Artículo disponible a través de PubMed Central. Artículo ahead of print - article in press.Background: Oral Pathology (OP) and Oral Medicine (OM) are specialties in dentistry whose main objective is the diagnosis and treatment of oral and maxillofacial ...
Reiván-Ortiz, Patricia, Sobral, Layanne, Flores-Ramos, Janeth, González-Galvan, María del Carmen, Santos-Leite, Éder Gerardo, Bologna-Molina, Ronell, Pena Vega, Claudia, Martelli-Júnior, Hercílio, González-Arriagada, Alejandro, Delgado-Azañero, Wilson, Martínez-Pedraza, Ricardo, Villarroel-Dorrego, Mariana, Gilligan, Gerardo, Benevenuto de Andrade, Bruno Augusto   +13 more
core   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Effect of the Oral Probiotics on Salivary Alpha-amylase, Buffering Capacity, pH, and Plaque Level among Dental Students – A Pilot Randomized Controlled Trial

Journal of Indian Association of Public Health Dentistry
Background: Saliva has been used as a potential diagnostic tool due to its ease, noninvasive accessibility, along with its numerous biomarkers. The use of salivary alpha amylase (SAA) as a biomarker for various diseases including carious lesion is a ...
S. Savitha Priyadarsini, Kamlesh Manohar Palandurkar, P. G. Naveen Kumar, Mahesh R. Khairnar, Zainab Akram, Ridhi Ghodela, Sachin Kumar Jadhav, Neha Shukla   +7 more
doaj   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source