Results 161 to 170 of about 2,246,271 (345)

MIGRENE: The Toolbox for Microbial and Individualized GEMs, Reactobiome and Community Network Modelling

Metabolites
Understanding microbial metabolism is crucial for evaluating shifts in human host–microbiome interactions during periods of health and disease. However, the primary hurdle in the realm of constraint-based modeling and genome-scale metabolic models (GEMs)
Gholamreza Bidkhori, Saeed Shoaie
doaj   +1 more source

Marsupial oral cavity microbiome

Microbiology Australia, 2015
Published: 6 March 2015 ; The oral microbiome of humans and animals will cause oral disease within their lifetimes and include a large number of endogenous cariogenic, periodontal and other opportunistic pathogens. Studies over many decades have attempted to determine which bacteria are involved in oral diseases.
Bird, P.S., Boardman, W.S.J., Trott, D.J., Blackall, L.L.   +3 more
openaire   +2 more sources

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source

Uncultured Members of the Oral Microbiome

Journal of the California Dental Association, 2016
Around one-third of oral bacteria cannot be cultured using conventional methods. Some bacteria have specific requirements for nutrients while others may be inhibited by substances in the culture media or produced by other bacteria. Oral bacteria have evolved as part of multispecies biofilms, and many thus require interaction with other bacterial ...
Wade, W, Thompson, H, Rybalka, A, Vartoukian, S   +3 more
openaire   +2 more sources

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Oral microbiome and its relationship with oral cancer

Journal of Cancer Research and Therapeutics
ABSTRACT As the initial point for digestion, the balance of oral microorganisms plays an important role in maintaining local and systemic health. Oral dysbiosis, or an imbalance in the oral microbial community, may lead to the onset of various diseases. The presence or abnormal increase of microbes in the oral cavity has attracted significant
Shengran, Wang, Xiao, Tan, Juan, Cheng, Zeyang, Liu, Huiping, Zhou, Jiyuan, Liao, Xijun, Wang, Hongyun, Liu   +7 more
openaire   +2 more sources

Oral Microbiome Characterization in Murine Models

BIO-PROTOCOL, 2017
The oral microbiome has been implicated as a trigger for immune responsiveness in the oral cavity, particularly in the setting of the inflammatory disease periodontitis. The protocol presented here is aimed at characterizing the oral microbiome in murine models at steady state and during perturbations of immunity or physiology.
Loreto Abusleme, Bo-Young Hong, Anilei Hoare, Joanne Konkel, Patricia Diaz, Niki Moutsopoulos   +5 more
openaire   +4 more sources

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source