Results 101 to 110 of about 2,327,342 (298)

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Endocrine-Taste Crosstalk: A Scoping Review on Thyroid Dysfunction and Its Genetic Links to Taste Receptors With Dysgeusia

International Journal of Endocrinology
Thyroid disorders are a common endocrine condition globally, affecting various bodily systems and metabolism. Changes in thyroid function affect smell and taste; yet, many patients remain unaware of their dysosmia and dysgeusia.
Panchami Pai, Ananya Chadaga, Srikant Natarajan, Chetana Chandrashekar, Gabriel Rodrigues, Sunitha Carnelio   +5 more
doaj   +1 more source

Relationship of fibrosis and the expression of TGF-β1, MMP-1, and TIMP-1 with epithelial dysplasia in oral submucous fibrosis [PDF]

, 2010
Background: Oral submucous fibrosis (OSF) is a premalignant fibrotic oral disease. The aim of this study was to investigate the relationship between fibrosis and the expression of TGF-β1, MMP-1, and TIMP-1 and epithelial dysplasia in OSF.
김진, 김기열
core   +1 more source

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

Investigating Oral Cancer Awareness Among Medical and Dental Students: A Cross-Sectional Study in the South Canara Region of India

The Scientific World Journal
Oral cancer is responsible for increased mortality, especially in the Indian subcontinent. Habits like smoking and tobacco chewing are among the most common causes of oral cancer.
Shubham Agarwal, Nidhi Manaktala, Srikant Natarajan, Karen Boaz   +3 more
doaj   +1 more source

Diagnostic Challenges of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the Hard Palate

Diagnostics
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion that may arise from the oral mucosa consisting in an ulcerative lesion usually localized in the tongue or cheek. Palate localization is very rare.
Giacomo Setti, Stefania Caramaschi, Giuseppe Barile, Antonio d’Amati, Marta Forte, Giuseppe D’Albis, Pierantonio Bellini, Giovanna Garuti, Luisa Limongelli, Saverio Capodiferro   +9 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Oral Malignant Melanoma: The Amsterdam Experience

, 2007
Purpose: The purpose of this study was to evaluate the clinical, pathological, and therapeutic experience of a group of patients with primary oral malignant melanoma (OMM) in Amsterdam, The Netherlands. Patients and Methods: Fourteen patients (5 males, 9
van der Waal, Isaäc, Leemans, C. René, Meleti, Marco, Mooi, Wolter J.   +3 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Cyclin D1 Expression for Risk Assessment of Malignant Transformation in Oral Precancerous Lesions

, 2001
The early detection of precancerous lesions potentially progressing to malignant tumors is critically important to reduce cancer incidence. Epithelial dysplasia has been considered as a reliable histologic hallmark to define premalignant lesions. But the
육종인, 김진, 차인호
core