Results 111 to 120 of about 369,599 (259)

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Evaluation of histological artefacts in oral pathology laboratory: A cross-sectional study. [PDF]

J Oral Maxillofac Pathol
Muthumanickam P, Pandiar D, Krishnan RP.
europepmc   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Human versus artificial intelligence in oral pathology diagnosis: a comparative study of ChatGPT, Grok, and MANUS. [PDF]

Sci Rep
Alshammari AF, Madfa AA, Anazi BA.
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

ChatGPT in Oral Pathology: Bright Promise or Diagnostic Mirage. [PDF]

Medicina (Kaunas)
Suárez A, Freire Y, Díaz-Flores García V, Santamaría Laorden A, Orejas Pérez J, Suárez Ajuria M, Algar J, Martín Carreras-Presas C.   +7 more
europepmc   +1 more source

Oral pathology [PDF]

British Dental Journal, 2005
openaire   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Profile and satisfaction of oral pathology/medicine postgraduates: a national multicenter study. [PDF]

Med Oral Patol Oral Cir Bucal
Ferreira LM, Maia-Lima MP, Trezena S, Nascimento JP, Oliveira FE, Duarte ÁA, Martelli DR, Alves FD, Freitas RD, Santos JN, Aguiar MC, Lopes MA, Bonan PR, Almeida JD, Martelli-Júnior H.   +14 more
europepmc   +1 more source

Changes in oral pathology teaching methods during the COVID-19 pandemic and the impact on student performance (oral pathology teaching changes during the COVID-19 pandemic). [PDF]

J Dent Sci, 2023
Cui JH, Ikeda C, Suzuki K, Isono H, Hisano Y, Yamamoto Y, Yoshikane T, Okamura T, Tominaga K.   +8 more
europepmc   +1 more source