Results 21 to 30 of about 370,051 (259)

Exploring the chemical space of protein–protein interaction inhibitors through machine learning

Scientific Reports, 2021
Although protein–protein interactions (PPIs) have emerged as the basis of potential new therapeutic approaches, targeting intracellular PPIs with small molecule inhibitors is conventionally considered highly challenging.
Jiwon Choi, Jun Seop Yun, Hyeeun Song, Nam Hee Kim, Hyun Sil Kim, Jong In Yook   +5 more
doaj   +1 more source

“The Standard Procedure” for Investigation of Oral Neutrophils in Oral Diseases

International Journal of Dentistry, 2023
Aim. There is need of an objective “standard procedure” that is reliable and clinically applicable for estimating oral neutrophil content in relation to oral diseases. Methods.
Peter Østrup Jensen, Pernille Dukanovic Rikvold, Kristine Røn Larsen, Mette Rose Jørgensen, Camilla Kragelund   +4 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Plasma Cell Mucositis: A Differential Diagnosis–Oriented Case Report

Case Reports in Dentistry
We present the case of an 80-year-old woman who reported painful gingival swelling and bleeding gums persisting for 6 months. She had hypertension (treated with amlodipine and losartan), arrhythmia (digoxin), and hypothyroidism (levothyroxine ...
Matías Klare Rojas, Victoria Rees Moral, René Jara Moya, Isidora Mujica Valenzuela, Sergio González Providell   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Disrupted tenogenesis in masseter as a potential cause of micrognathia

International Journal of Oral Science, 2022
Micrognathia is a severe craniofacial deformity affecting appearance and survival. Previous studies revealed that multiple factors involved in the osteogenesis of mandibular bone have contributed to micrognathia, but concerned little on factors other ...
Chao Liu, Nan Zhou, Nan Li, Tian Xu, Xiaoyan Chen, Hailing Zhou, Ailun Xie, Han Liu, Lei Zhu, Songlin Wang, Jing Xiao   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease

Journal of Immunology Research
Sjögren disease (SjD) is an autoimmune disorder that predominantly affects the exocrine glands, and advancing age is recognized as an important risk factor for its development.
Mari Nishida, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Aya Ushio, Takaaki Tsunematsu, Keiko Aota, Naozumi Ishimaru   +7 more
doaj   +1 more source

Keratocystoma of palatal minor salivary glands: a case report

Journal of Oral Medicine and Oral Surgery
Keratocystoma is a rare benign tumor of the salivary glands. Initially described as a choristoma by Seifert et al. in 1999, the term “keratocystoma” was later proposed by Nagao et al. in 2001. The parotid gland is the most common site of occurrence. Only
Benaouf Souad, Kraloua Saadia, Larbi Meriem, El Amine Khebichat Moncef, Tabeti-Bentahar Cherifa Faiza   +4 more
doaj   +1 more source