Results 71 to 80 of about 81,418 (186)

Oral potentially malignant disorders in oropharyngeal squamous cell carcinoma

Актуальные проблемы теоретической и клинической медицины
The purpose of the study is to investigate the relationships between oropharyngeal squamous cell carcinoma and clinically diagnosed potentially malignant diseases of the oral cavity.Methods.
D. Sh. Polatova, A. Yu. Madaminov, K. E. Shomurodov, D. A. Ibragimova, A. I. Nurzhabov, N. K. Asameddinov, L. A. Akhmadboev   +6 more
doaj   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Potentially Malignant Disorders Of Oral Cavity

, 2011
Even though rapid advances have been made in the field of medicine and surgery, cancer is the leading cause for human mortality. It is estimated that more than one million new oral cancer cases are being detected annually in the Indian subcontinent, of which 90% are oral squamous cell carcinomas (OSCC).
George, Anthony, Sreenivasan BS, S, Sunil, Varghese SS, J, Thomas, Gopakumar D, V, Mani   +6 more
openaire   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

AI‐Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue

Advanced Science, EarlyView.
A fully integrated vibration‐assisted capsule is presented for the minimally invasive detection of bowel lesions. The capsule incorporates a wireless sensor and an eccentric motor to probe tissue mechanics in situ. By coupling triaxial vibration signals with AI‐based classification and analytical modeling, the system enables early, non‐visual ...
Xizheng Fang, Yao Yan, Kenneth Omokhagbo Afebu, Andrew Bickerdike, Bo Tian, Yang Liu, Shyam Prasad   +6 more
wiley   +1 more source

Immunoglobulin a in oral potentially malignant disorders and oral squamous cell carcinoma

Journal of Medical Sciences, 2017
Introduction: Oral squamous cell carcinomas (OSCCs) are malignancies which develop predominantly from preexisting potentially malignant disorders. Immunoglobulin A (IgA) in saliva and serum is responsible for local immune response.
Vidya Ajila, Veena Shetty, Subhas Babu, Shruthi Hegde, Shama Rao   +4 more
doaj   +1 more source

Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

Medicina Oral Patología Oral y Cirugia Bucal, 2014
Leukoplakia is the most common potentially malignant disorder of the oral mucosa. The prevalence is approximately 1% while the annual malignant transformation ranges from 2% to 3%. At present, there are no reliable clinicopathological or molecular predicting factors of malignant transformation that can be used in an individual patient and such event ...
openaire   +8 more sources

Oral potentially malignant disorders: A lot more to explore

Journal of Oral Biology and Craniofacial Research, 2021
Naman R. Rao, BDS, MMSc
doaj   +1 more source

A study of risk factors associated with the presence of oral potentially malignant disorders: a community-based study from Northeastern Thailand

BMC Oral Health
Background The principal objective of this study is to ascertain the connections between well-known risk factors of oral cancer, including smoking (cigarette and tobacco), alcohol consumption, betel quid chewing, irritations in the oral cavity, history ...
Pim Chiewwit, Siribang-on Piboonniyom Khovidhunkit, Chanita Tantipoj, Prangtip Worakhajit, Boworn Klongnoi   +4 more
doaj   +1 more source