Results 221 to 230 of about 5,586,070 (250)

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Validated RP-HPLC-UV Method for the Quantitative Analysis and Stability Evaluation of Amoxicillin in Paediatric Gummy Tablets. [PDF]

Electrophoresis
Bonafè S, Imbriano A, Pagano C, Migni A, Bianconi E, Mercolini L, Perioli L, Sardella R.   +7 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Development and validation of an artificial intelligence proof-of-concept tool for risk-based quality assessment of generic medicines: a South African case study. [PDF]

Front Med (Lausanne)
Danks L, Semete-Makokotlela B, Reynecke C, Dijeng S, Kgosietsile B, van Tonder J, van Graan C, Hinch J, Kruger A, Walker S, Salek S.   +10 more
europepmc   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Hot-Melt Pneumatic Extrusion-Based 3D-Printed Bilayer Tablets Enabling Sequential Release of Levocetirizine and Montelukast. [PDF]

Pharmaceutics
Kim GR, Cho JY, Lee SW, Jin HE.
europepmc   +1 more source

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

Formulation Strategies to Enhance the Solubility of Poorly Water-Soluble Drugs and Phytochemicals: Current Advances and Challenges. [PDF]

Pharmaceutics
Jacob S, Shah H, Nair AB.
europepmc   +1 more source

A University-Led Take-Back Program for Pharmaceutical Waste Management: Eleven Years of Real-World Evidence on Medication Non-Use and Disposal Patterns. [PDF]

Pharmacy (Basel)
Hernández-Rangel AE, Hernández-Fuentes GA, Delgado-Enciso I, Parra-Delgado H, Castrejón-Antonio JE, Galván-Salazar HR, Olvera-Montejano A, Guzmán-Esquivel J, Rojas-Larios F, Delgado-Enciso J, Silva-Vázquez CG, Díaz-Llerenas U, Sánchez-Galindo JM, Alcalá-Pérez MA, Montes-Galindo DA.   +14 more
europepmc   +1 more source

The Role and Potential of Nanotechnology in Improving Solubility and Enhancing Bioavailability. [PDF]

Pharmaceutics
Hosszú Z, Pártos P, Mahdavi M, Ujhelyi Z, Fehér P, Haimhoffer Á, Bácskay I, Kósa D, Pető Á.   +8 more
europepmc   +1 more source