Results 41 to 50 of about 645,034 (313)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Prevalence of Oral Pain and Barriers to use of Emergency Oral Care Facilities Among Adult Tanzanians. [PDF]

, 2008
Oral pain has been the major cause of the attendances in the dental clinics in Tanzania. Some patients postpone seeing the dentist for as long as two to five days.
Kikwilu Emil, Febronia Kokulengya Kahabuka, Masalu, Joyce Rose, Kikwilu, Emil Namakuka, Senkoro, Ahadieli Raphael, Kahabuka Febronia, Masalu, J.R., Joyce Rose Masalu, Emil Namakuka Kikwilu, Ahadieli Raphael Senkoro, Kahabuka, Febronia Kokulengya, Senkoro Ahadieli, Masalu Joyce, Kikwilu, E.N., Kahabuka, F.K., Senkoro, A.R.   +15 more
core   +1 more source

Impact of direct oral anticoagulants on bleeding tendency and postoperative complications in oral surgery : a systematic review of controlled studies [PDF]

, 2023
OBJECTIVE: The recommendations for the management of direct oral anticoagulants (DOACs) in oral surgery are inconsistent. The present review evaluated whether DOACs increase the risk of bleeding during oral surgery and postoperative complications.
Holst, Jan, Naimi-Akbar, Aron, Götrick, Bengt, Johansson, Krister, Tranæus, Sofia   +4 more
core   +1 more source

Long-Term Follow-Up of SAPHO Syndrome for 15 Years Led to a Diagnosis of Temporomandibular Joint Pain and Trismus

Case Reports in Dentistry, 2021
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a systemic disease with symptoms of pustular skin disease and sterile osteoarticular lesions. This disease rarely involves the temporomandibular joint (TMJ).
Koki Takamatsu, Hitoshi Sato, Takashi Moriya, Arisa Yasuda, Takaaki Kamatani, Tatsuo Shirota   +5 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Diagnostic Challenges in Differentiating Unicystic Ameloblastoma From Odontogenic Cysts: Report of Two Cases

Case Reports in Dentistry
Ameloblastomas are benign odontogenic tumors characterized by local aggressiveness and a high potential for recurrence. Unicystic ameloblastoma (UA) is an uncommon variant that often mimics odontogenic cysts, making preoperative diagnosis challenging ...
Chaima Khalifa, Maroua Garma, Afef Slim, Adel Bouguezzi, Sameh Sioud, Hajer Hentati   +5 more
doaj   +1 more source

Postoperative Complications of Impacted Mandibular Third Molar Extraction Related to Patient’s Age and Surgical Difficulty Level: A Cross-Sectional Retrospective Study

International Journal of Dentistry, 2022
Mandibular third molar surgical extraction, either partially erupted or fully impacted, is the most common surgical procedure in oral and maxillofacial surgery (OMFS).
Andra Rizqiawan, Yeni Dian Lesmaya, Anindita Zahratur Rasyida, Muhammad Subhan Amir, Shigehiro Ono, David Buntoro Kamadjaja   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Oral midazolam sedation in third molar surgery [PDF]

, 1987
A double-blind randomised study was designed to assess the value of oral midazolam in patients undergoing minor oral surgery. 30 young healthy Hong Kong Chinese with bilateral symmetrical impaction of lower third molars to be surgically removed in 2 ...
Rodrigo, MRC, Cheung, LK
core   +1 more source

Dynamic Navigation-Assisted Coronectomy of a Deeply Impacted Mandibular Third Molar: A 5-Year Case Follow-Up

Case Reports in Dentistry
Coronectomy is a conservative surgical technique used to manage deeply impacted mandibular third molars at high risk of inferior alveolar nerve injury.
Gerardo Pellegrino, Subhi Tayeb, Elisabetta Vignudelli, Claudia Angelino, Carlo Barausse, Pietro Felice   +5 more
doaj   +1 more source