Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao +8 more
wiley +1 more source
Betel nut chewing and its implications for airway management: a single-centre survey of knowledge and experience. [PDF]
Zhang X +4 more
europepmc +1 more source
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu +8 more
wiley +1 more source
Dentistry and dental care in antiquity: part 2 - Egypt and the Graeco-Roman World. [PDF]
Forshaw R.
europepmc +1 more source
Comparison of the Hebrew writings and Bible (Genesis 37 - 42) with Quranic Sura Yusuf as example for cultural adaption : a study of a cross-cultural differentiation process of textual and oral traditions for religious writings under the historical conditions of Middle East societies [PDF]
Haase, Fee-Alexandra
core
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Blackfoot legal traditions, treaty-making, and non-territorial forms of settler jurisdiction? Niitsitapi oral histories of Treaty 7. [PDF]
Fabris M.
europepmc +1 more source
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang +10 more
wiley +1 more source
The Therapeutic Benefits of Outdoor Experiences in India. [PDF]
Mitra SJ +3 more
europepmc +1 more source

