Results 181 to 190 of about 1,739,037 (393)

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Keratoconus and quality of life: an updated comprehensive review

open access: yesBMC Ophthalmology
Keratoconus (KCN), a progressive ectatic corneal disorder, significantly impacts vision-related quality of life (VRQoL) beyond reduced visual acuity. This review aims to comprehensively examine the impact of keratoconus on patients’ quality of life (QoL),
Seyed Mohsen Rafizadeh   +3 more
doaj   +1 more source

Bayesian Adaptive Extended Kalman-Based Orbit Determination for Optical Observation Satellites

open access: yesSensors
As the number of satellites and amount of space debris in Low-Earth orbit (LEO) increase, high-precision orbit determination is crucial for ensuring the safe operation of spacecraft and maintaining space situational awareness.
Yang Guo   +6 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Ectopic dacryops mimicking a lacrimal sac tumor: A case report and literature review

open access: yesAmerican Journal of Ophthalmology Case Reports
Purpose: To report a rare case of dacryops found within the lacrimal sac, which mimicked a lacrimal sac tumor. Observations: An adult female patient presented with epiphora and chronic swelling of the lacrimal sac, initially raising concerns for a ...
Abdulrahman Alfarhan   +5 more
doaj   +1 more source

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