Results 161 to 170 of about 3,161,815 (352)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Impact of the Initial State on BDS Real-Time Orbit Determination Filter Convergence [PDF]

, 2018
Yun Qing, Yidong Lou, Yang Liu, Xiaolei Dai, Yi Cai   +4 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cosmic background explorer (COBE) navigation with TDRSS one-way return-link Doppler in the post-helium-venting phase [PDF]

A navigation experiment was performed which establishes Ultra-Stable Oscillator (USO) frequency stabilized one way return link Doppler TDRSS tracking data as a feasible option for mission orbit determination support at the Goddard Space Center Flight ...
Dunham, J., Jackson, J., Maher, M., Nemesure, M., Teles, J.   +4 more
core   +1 more source

Experimental Determination of a Single Atom Ground State Orbital through Hyperfine Anisotropy [PDF]

, 2022
Laëtitia Farinacci, Lukas M. Veldman, Philip Willke, A. F. Otte   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Influence of Time Intervals: Comparative Analysis of Short-Arc Orbit Determination for GEO Satellites Using AER and RNG Methods

Havacılık ve Uzay Teknolojileri Dergisi
Short arc orbit determination for GEO satellites is useful when there are gaps or incomplete data due to limited time or other factors. Full cycle orbit determination requires continuous data over the entire orbit cycle, which may not always be available.
Ümit Cezmi Yılmaz, Ümit Güler, Cemal Şakacı, İbrahim Öz   +3 more
doaj  

Autonomous satellite orbit determination during the development phases of the global positioning system [PDF]

An onboard navigation system was developed to aid the design and evaluation of algorithms used in autonomous satellite navigation with Global Positioning System (GPS) data. The performance of the algorithms designed for a GPS Receiver/Processor Assembly (
Dunham, J. B.
core   +1 more source

Elements of orbit-determination theory - Textbook [PDF]

, 1971
Text applies to solution of various optimization problems. Concepts are logically introduced and refinements and complexities for computerized numerical solutions are avoided.
Solloway, C. B.
core   +1 more source

Multi-resonance orbital model of high-frequency quasi-periodic oscillations: possible high-precision determination of black hole and neutron star spin [PDF]

, 2013
Zdeněk Stuchlík, Andrea Kotrlová, Gabriel Török   +2 more
openalex   +1 more source