Results 141 to 150 of about 22,697 (311)
Improving the geometry of Kaguya extended mission data through refined orbit determination using laser altimetry. [PDF]
Icarus, 2020 Goossens S +4 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Spacecraft orbit determination techniques using stellar occultations
openLa determinazione orbitale permette di ricostruire e predire la traiettoria di un satellite artificiale nello spazio. Ad oggi, le tecniche più utilizzate per ottenere le misure necessarie per questo tipo di analisi sono: quelle che ricavano ...
BANZI, DAVIDE
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Havacılık ve Uzay Teknolojileri DergisiShort arc orbit determination for GEO satellites is useful when there are gaps or incomplete data due to limited time or other factors. Full cycle orbit determination requires continuous data over the entire orbit cycle, which may not always be available.
Ümit Cezmi Yılmaz +3 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Relative estimate of accuracy in orbit determination from a short tracklet
, 2015 The Astronomical Institute of the University of Bern (AIUB) is conducting several search campaigns for orbital debris. The debris objects are discovered during systematic survey observations.
Schildknecht, Thomas +1 more
core
Determination of onboard coplanar orbital maneuvers with orbits determined using GPS
, 2014 In the present paper a study is made in order to find an algorithm that can calculate coplanar orbital maneuvers for an artificial satellite. The idea is to find a method that is fast enough to be combined with onboard orbit determination using GPS data collected from a receiver that is located in the satellite.
Chiaradia, Ana Paula Marins +2 more
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source