Results 121 to 130 of about 1,818,861 (299)

Mars Express tracking and orbit determination trials with Chinese VLBI network

, 2010
With strong support from European Space Agency (ESA), Shanghai Astronomical Observatory (SHAO) organized a tracking and orbit determination trails using Chinese VLBI Network (CVN) to track Mars Express, the first Mars probe launched by ESA.
Ma MaoLi, Zheng WeiMin, Cao JianFeng, Hu XiaoGong, Huang Yong   +4 more
core   +1 more source

Realtime Precise Orbit Determination Technology for LEO Mega-Constellation

天地一体化信息网络
Supported by GNSS, it analyzed the advantages and disadvantages of solving LEO satellite orbit on the ground or onboard the satellites.The high-fidelity non-conservative force models were applied to the real-time orbit determination algorithm.To separate
Zhen LI, Chuang SHI
doaj   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Bistatic SAR Imaging and Precise Orbit Determination Using Geostationary Telecommunication Satellites

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
SAR satellite missions from geostationary orbits (GEOSAR) would offer the short revisit times required in the observation of fast phenomena. Ground-based multiple baseline interferometry is a technique under study for precise orbit determination of GEO ...
Xavier Carreno-Megias, Jorge Nicolas-Alvarez, Antoni Broquetas, Albert Aguasca, Joan Cuy-Saques, Marius Gutierrez   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Relative estimate of accuracy in orbit determination from a short tracklet [PDF]

, 2015
The Astronomical Institute of the University of Bern (AIUB) is conducting several search campaigns for orbital debris. The debris objects are discovered during systematic survey observations.
Schildknecht, Thomas, Vananti, Alessandro   +1 more
core  

Dealing with uncertainties in angles-only initial orbit determination

, 2016
A method to deal with uncertainties in initial orbit determination (IOD) is presented. This is based on the use of Taylor differential algebra (DA) to nonlinearly map uncertainties from the observation space to the state space.
Armellin, R. [0000-0002-3516-6428], Zanetti, R., Armellin, R, Zanetti, R, Di Lizia, P, Di Lizia, P. [0000-0003-1692-3929]   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source