Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Applied Sciences, 2023 The Changchun Observatory of the National Astronomical Observatories, Chinese Academy of Sciences, and the Shanghai Astronomical Observatory are used to generate very short arc (VSA) angle observations of objects in low Earth orbit (LEO) and ...
Xiangxu Lei +8 more
doaj +1 more source
LEO Precise Orbit Determination with Inter-Satellite Links
Remote Sensing, 2019 Traditional precise orbit determination (POD) for low Earth orbit (LEO) satellites relies on observations from ground stations and onboard receivers.
Xingxing Li +5 more
semanticscholar +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Development Strategy of Orbit Determination System for Korea’s Lunar Mission: Lessons from ESA, JAXA, ISRO and CNSA’s Experiences [PDF]
Journal of Astronomy and Space Sciences, 2014 In this paper, a brief but essential development strategy for the lunar orbit determination system is discussed to prepare for the future Korea’s lunar missions.
Young-Joo Song, Sang-il Ahn, Eun-Sup Sim
doaj +1 more source
Integrated Precise Orbit Determination of Multi-GNSS and Large LEO Constellations
Remote Sensing, 2019 Global navigation satellite system (GNSS) orbits are traditionally determined by observation data of ground stations, which usually need even global distribution to ensure adequate observation geometry strength.
Xingxing Li +8 more
semanticscholar +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Comparison of Autonomous Orbit Determination for Satellite Pairs in Lunar Halo and Distant Retrograde Orbits [PDF]
, 2022 Zhao-Yang Gao, Xiyun Hou
openalex +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
A geometric model for Hochschild homology of Soergel bimodules
, 2007 An important step in the calculation of the triply graded link homology theory of Khovanov and Rozansky is the determination of the Hochschild homology of Soergel bimodules for SL(n).
Akyıldız +5 more
core +3 more sources