Results 71 to 80 of about 3,365,879 (300)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Orbit Propagation and Determination of Low Earth Orbit Satellites

International Journal of Antennas and Propagation, 2014
This paper represents orbit propagation and determination of low Earth orbit (LEO) satellites. Satellite global positioning system (GPS) configured receiver provides position and velocity measures by navigating filter to get the coordinates of the orbit ...
Ho-Nien Shou
doaj   +1 more source

Probabilistic Methods for Initial Orbit Determination and Orbit Determination in Cislunar Space

CoRR
In orbital mechanics, Gauss's method for orbit determination (OD) is a popular, minimal assumption solution for obtaining the initial state estimate of a passing resident space object (RSO). Since much of the cislunar domain relies on three-body dynamics, a key assumption of Gauss's method is rendered incompatible, creating a need for a new, minimal ...
Ishan Paranjape, Tarun Hejmadi, Suman Chakravorty   +2 more
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Precise orbit determination for representative near-Earth asteroids based on optical observations of ground-based stations and the Earth-Moon L1 point’s orbit

Geo-spatial Information Science
Precise orbit determination of near-Earth asteroids (NEAs) provides a critical foundation for exploration missions. Considering that cislunar space is a critical domain for future human space activities and the unique positional advantage of the Earth ...
Zhenqi Wang, Jianguo Yan, Wutong Gao, Shangbiao Sun, Zhen Wang, Wanling Yang, Hakim Saibi, Jean-Pierre Barriot   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Enhanced Real-Time Onboard Orbit Determination of LEO Satellites Using GPS Navigation Solutions with Signal Transit Time Correction

Aerospace
Enhanced real-time onboard orbit determination for low-Earth-orbit satellites is essential for autonomous spacecraft operations. However, the accuracy of such systems is often limited by signal propagation delays between GPS satellites and the user ...
Daero Lee, Soon Sik Hwang
doaj   +1 more source

LEO Precise Orbit Determination with Inter-Satellite Links

Remote Sensing, 2019
Traditional precise orbit determination (POD) for low Earth orbit (LEO) satellites relies on observations from ground stations and onboard receivers.
Xingxing Li, Zihao Jiang, Fujian Ma, Hongbo Lv, Yong-Qiang Yuan, Xin Li   +5 more
semanticscholar   +1 more source