Results 71 to 80 of about 20,106 (266)

The Dynamical History of HIP-41378 f—Oblique Exorings Masquerading as a Puffy Planet

open access: yesThe Astrophysical Journal
The super-puff HIP-41378 f represents a fascinating puzzle due to its anomalously low density on a far-out orbit in contrast with other known super-puffs.
Tiger Lu   +3 more
doaj   +1 more source

Magnetization dynamics driven by non-equilibrium spin-orbit coupled electron gas

open access: yesNew Journal of Physics, 2015
The dynamics of magnetization coupled with an electron gas via s-d exchange interaction is investigated by using the density matrix technique. Our theory shows that nonequilibrium spin accumulation induces a spin torque and the electron bath leads to a ...
Yong Wang, Wei-qiang Chen, Fu-Chun Zhang
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Propagation of Space Objects

open access: yesJournal of Aerospace Technology and Management, 2015
Actual, important problems of space dynamics are related to the protection of the Earth and its close space environment. This includes the study of disposal strategies for artificial satellites, the real-time propagation of space catalogues of thousands
Martin Lara   +3 more
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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