Results 131 to 140 of about 14,014 (297)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Improving FermiI Orbit Determination and Prediction in an Uncertain Atmospheric Drag Environment [PDF]

, 2014
Orbit determination and prediction of the Fermi Gamma-ray Space Telescope trajectory is strongly impacted by the unpredictability and variability of atmospheric density and the spacecrafts ballistic coefficient.
Vavrina, Matthew A., Slojkowski, Steven E., Carpenter, J. Russell, Newman, Clark Patrick   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Improving Fermi Orbit Determination and Prediction in an Uncertain Atmospheric Drag Environment [PDF]

, 2014
Orbit determination and prediction of the Fermi Gamma-ray Space Telescope trajectory is strongly impacted by the unpredictability and variability of atmospheric density and the spacecraft's ballistic coefficient.
Vavrina, Matthew A., Slojkowski, Steven E., Carpenter, J. Russell, Newman, Clark P.   +3 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

FedSat Orbit Determination: Results From Daily GPS Flight Code Observations [PDF]

, 2003
The Australian Federation Satellite, FedSat, was successfully launched into a 780-km low-earth orbit on 14 December 2002. Since then, the onboard Blackjack GPS receiver has operated on a duty cycle basis, providing effective data sets at an average of 10
Enderle, Werner, Feng, Yanming, Zhou, Ning   +2 more
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Non-Keplerian orbits using hybrid solar sail propulsion for Earth applications [PDF]

, 2012
Half a century of space technology development has provided a wealth of new space applications. However, many still remain to be explored. Examples include increased geostationary coverage and new opportunities to enhance polar observation.
Biggs, James, Heiligers, Jeannette, McInnes, Colin, Ceriotti, Matteo   +3 more
core  

A VMD-SVM Method for LEO Satellite Orbit Prediction with Space Weather Parameters

Remote Sensing
The technology of satellite orbit prediction (OP) is crucial in space engineering. However, it is difficult to precisely predict medium and long-term orbit for the low Earth-orbit (LEO) satellites because of time-varying space weather and inaccurate ...
Hao Xu, Jiahao Liao, Yufei Luo, Yunhe Meng   +3 more
doaj   +1 more source