Results 141 to 150 of about 142,927 (339)

Predicting RSO populations using a neighbouring orbits technique

open access: yesRAS Techniques and Instruments
Abstract The determination of the full population of resident space objects (RSOs) in low Earth orbit (LEO) is a key issue in the field of space situational awareness that will only increase in importance in the coming years. We endeavour to describe a novel method of inferring the population of RSOs as a function of orbital height and ...
Benjamin F Cooke   +4 more
openaire   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

An Improved Laplace Satellite Tracking Method Based on the Kalman Filter

open access: yesAerospace
When photoelectric measuring equipment is used to track satellites, the extraction of the short-term or long-term target often fails because the target is weak, clouds block the target, and/or the sun’s angle is too small, resulting in the loss of the ...
Shuang Cui   +6 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Predictability in orbital reconstruction

open access: yes, 2016
The aim of this thesis is to evaluate the current standards in diagnostics and treatment of orbital fractures. The principles of orbital reconstruction are described and the biggest controversies are debated. By three systematic reviews, the indications in relation to fracture size and location are discussed, as well as the optimal timing and the most ...
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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