Results 41 to 50 of about 10,695 (212)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
An Autonomous Orbit Prediction Approach for BDS MEO Satellites Using a Short-Sequence Adaptive Model
Remote SensingThe new-generation global navigation satellite system (GNSS) demands enhanced satellite autonomy, where high-precision orbit prediction plays a pivotal role. Traditional dynamic models depend heavily on long-term on-orbit observations, making hybrid deep-
Yihui Zhao +4 more
doaj +1 more source
The Short‐Time Prediction of Thermospheric Mass Density Based on Ensemble‐Transfer Learning
Space Weather, 2023 Reliable short‐time prediction of thermospheric mass density along the satellite orbit is always essential but challenging for the operation of Low‐Earth orbit satellites.
Peian Wang +7 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Proposed Orbital Products for Positioning Using Mega-Constellation LEO Satellites
Sensors, 2020 With thousands of low Earth orbit (LEO) satellites to be launched in the near future, LEO mega-constellations are supposed to significantly change the positioning and navigation service for ground users.
Kan Wang, Ahmed El-Mowafy
doaj +1 more source
Orbit Prediction using Broadcast Ephemeris for GLONASS Satellite Visibility Analysis [PDF]
Journal of Astronomy and Space Sciences, 2009 Even though there are several Global Navigation Satellite Systems under development, only GPS and GLONASS are currently available for satellite positioning.
Hye-In Kim, Kwan-Dong Park
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source