Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Orbit evolution, maintenance and disposal of SpaceChip swarms [PDF]
The combined effect of solar radiation pressure and atmospheric drag is investigated for future mission conceptsfor swarms of satellites-on-a-chip (SpaceChips). The natural evolution of the swarm is exploited to perform spatially distributed measurements
Colombo, C. +2 more
core +3 more sources
Orbit design for future SpaceChip swarm missions in a planetary atmosphere [PDF]
The effect of solar radiation pressure and atmospheric drag on the orbital dynamics of satellites-on-a-chip (SpaceChips) is exploited to design equatorial long-lived orbits about the oblate Earth.
Colombo, Camilla, McInnes, Colin
core +4 more sources
Proposed Orbital Products for Positioning Using Mega-Constellation LEO Satellites
With thousands of low Earth orbit (LEO) satellites to be launched in the near future, LEO mega-constellations are supposed to significantly change the positioning and navigation service for ground users.
Kan Wang, Ahmed El-Mowafy
doaj +1 more source
The Short‐Time Prediction of Thermospheric Mass Density Based on Ensemble‐Transfer Learning
Reliable short‐time prediction of thermospheric mass density along the satellite orbit is always essential but challenging for the operation of Low‐Earth orbit satellites.
Peian Wang +7 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An Autonomous Orbit Prediction Approach for BDS MEO Satellites Using a Short-Sequence Adaptive Model
The new-generation global navigation satellite system (GNSS) demands enhanced satellite autonomy, where high-precision orbit prediction plays a pivotal role. Traditional dynamic models depend heavily on long-term on-orbit observations, making hybrid deep-
Yihui Zhao +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Orbit Prediction using Broadcast Ephemeris for GLONASS Satellite Visibility Analysis [PDF]
Even though there are several Global Navigation Satellite Systems under development, only GPS and GLONASS are currently available for satellite positioning.
Hye-In Kim, Kwan-Dong Park
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source

