Results 91 to 100 of about 164,630 (292)

Mechanistic study of targeting melanoma with STING pathway deficiencies via PIKfyve inhibitor

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the antitumor effects and potential mechanisms of combining phosphoinositide 3-kinase, FYVE-type zinc finger containing (PIKfyve) inhibitor YM201636 with the stimulator of interferon genes (STING) agonist diABZI in STING pathway ...
YANG Xiaoyu, HUANG Rui, WU Yijia, ZHANG Zhe, FANG Yan, SHEN Jianfeng   +5 more
doaj   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

Clinicopathological and genetic analysis of orbital solitary fibrous tumors

BMC Ophthalmology
Purpose To investigate the clinicopathological and genetic characteristics of patients with orbital solitary fibrous tumor (SFT) for clinical reference. Methods This single-center retrospective case-series study assessed clinical manifestations, imaging ...
Qing Wang, Zonghan Nan, Xun Liu, Limin Zhu, Emmanuel Eric Pazo, Tianming Jian, Liang Zhao, Jinzhi Zhao, Tingting Lin   +8 more
doaj   +1 more source

Expression of Tumor Assosiated and Epithelial-mesenchymal Transition Markers in 2d and 3d Cell Cultures of Mcf-7 [PDF]

, 2016
The target effects on the expression of epithelial-mesenchymal transition regulation molecules are promising for cancer therapy, including breast cancer.
Herheliuk, T. (Tetiana), Ostapchenko, L. (Lyudmila), Perepelytsina, O. (Olena), Sydorenko, M. (Mykhailo), Yurchenko, N. (Natalia)   +4 more
core   +2 more sources

Variability in Nonvitamin K Oral Anticoagulant Dose Eligibility and Adjustment According to Renal Formulae and Clinical Outcomes in Patients With Atrial Fibrillation With and Without Chronic Kidney Disease: Insights From ORBIT‐AF II [PDF]

, 2023
Ren Jie Robert Yao, DaJuanicia N. Holmes, Jason G. Andrade, Adeera Levin, Jonathan P. Piccini, Christopher B. Fordyce   +5 more
openalex   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Clinical Use of S53P4 Bioactive Glass in the Treatment of Bone Defects and Infected Bone: A Systematic Review of the Quality of Clinical Outcomes and A Grade Assessment

Advanced Healthcare Materials, EarlyView.
Bioactive glass (BAG) S53P4 is a synthetic bone substitute. Clinically it has been used in the treatment of benign bone tumor surgery, in spine surgery, in trauma surgery, in frontal sinus surgery, in diabetic foot osteomyelitis surgery, in mastoid surgery, in oral and maxillofacial surgery in more than 4000 patients, with excellent clinical long‐term ...
Sebastian CE Lindfors, Chris JJ Arts, Nina C Lindfors   +2 more
wiley   +1 more source

Turmeric and black pepper spices decrease lipid peroxidation in meat patties during cooking. [PDF]

, 2015
Spices are rich in natural antioxidants and have been shown to be potent inhibitors of lipid peroxidation during cooking of meat. Turmeric contains unique conjugated curcuminoids with strong antioxidant activity. Piperine, one of the main constituents of
Heber, David, Henning, Susanne M, Huang, Jianjun, Lee, Ru-Po, Li, Zhaoping, Zerlin, Alona, Zhang, Yanjun   +6 more
core   +2 more sources

Orbital manifestation of immune reconstitution inflammatory syndrome in Whipple’s Disease

, 2022
Gerhard E. Feurle, Verena Moos
openalex   +2 more sources