Results 51 to 60 of about 255,622 (355)

Identification of immune hub genes participating in the pathogenesis and progression of Vogt-Koyanagi-Harada disease

open access: yesFrontiers in Immunology, 2022
BackgroundVogt-Koyanagi-Harada (VKH) disease is an autoimmune inflammatory disorder characterized by bilateral granulomatous uveitis. The objective of this study was to identify immune hub genes involved in the pathogenesis and progression of VKH disease.
Yiqi Wang   +14 more
doaj   +1 more source

Forecasting Disease Burden In Philippines: A Symbolic Regression Analysis [PDF]

open access: yesarXiv, 2021
Burden of disease measures the impact of living with illness and injury and dying prematurely and it is increasing worldwide leading cause of death both global and national. This paper aimed to propose an index of diseases and evaluate a mathematical model to describe the number of burden of disease by cause in the Philippines from 1990 - 2016. Through
arxiv  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Disseminated hydatid disease in the orbit and central nervous system [PDF]

open access: yesInternational Journal of Ophthalmology, 2021
Ming-Shen Ma   +4 more
doaj   +1 more source

Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

open access: yesJournal of Pharmaceutical Analysis, 2023
Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis.
Xiang Gu   +8 more
doaj  

Long Non-coding RNA LINC-PINT Suppresses Cell Proliferation and Migration of Melanoma via Recruiting EZH2

open access: yesFrontiers in Cell and Developmental Biology, 2019
Long non-coding RNAs (lncRNAs) have been identified as crucial regulators in many human cancers. Many lncRNAs show aberrant expression in cancer, and some of them play critical roles in tumor proliferation, invasion, and metastasis.
Yangfan Xu   +20 more
doaj   +1 more source

Traumatic endophthalmitis and the outcome after vitrectomy in young children [PDF]

open access: yesInternational Journal of Ophthalmology, 2020
"AIM: To explore the traumatic endophthalmitis in young children and the outcome of pars plana vitrectomy (PPV). METHODS: Twenty-two eyes of 22 cases of young children consecutive pediatric traumatic endophthalmitis treated and followed up between ...
Ya-Li Zhou   +4 more
doaj   +1 more source

WKB theory of epidemic fade-out in stochastic populations [PDF]

open access: yesPhys. Rev. E 80, 041130 (2009), 2009
Stochastic effects may cause fade-out of an infectious disease in a population immediately after an epidemic outbreak. We develop WKB theory to determine the most probable path of the system toward epidemic fade-out and to evaluate the fade-out probability.
arxiv   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

The Optic Canal: A Bottleneck for Cerebrospinal Fluid Dynamics in Normal-Tension Glaucoma? [PDF]

open access: yes, 2017
PURPOSE: To report on the optic canal cross-sectional area (OCA) in Caucasian patients with normal-tension glaucoma (NTG) compared with Caucasian control subjects without known optic nerve (ON) diseases.
Achmed Pircher   +4 more
core   +1 more source

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