Results 111 to 120 of about 599,612 (252)

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Through the Eyes of Trauma – Understanding Ocular Injuries and Orbital Fractures in Road Traffic Accidents

TNOA Journal of Ophthalmic Science and Research
Aim: To study the spectrum of ophthalmic manifestations and visual outcomes in patients with orbital wall fracture following road traffic accidents (RTAs).
Mohan Abhirrami, R Parthibavijayan, Sridhar Baratan   +2 more
doaj   +1 more source

UNUSUAL PENETRATING INJURY OF THE ORBIT [PDF]

British Journal of Ophthalmology, 1965
M, LALLA, S, PILLAI
openaire   +2 more sources

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Unusual pathway of intracranial foreign bodies in transorbital-penetrating injury: Exploring uncharted routes

Indian Journal of Ophthalmology. Case Reports
Transorbital-penetrating injuries are rare but can be severe, often affecting deeper skull structures, including the brain. They account for 4.5% of orbital pathologies and 0.04% of head injuries, with foreign objects rarely traversing ocular structures ...
Prabha Gupta, Priyanka Uraiya, Ritu Agrawal, Shreya Tripathi, Avinash Sharma, Pramod K. Chhawania   +5 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Orbital reconstruction: From simple materials to bioengineered solutions

Chinese Journal of Plastic and Reconstructive Surgery
Orbital fractures are a frequent and serious problem for practicing ophthalmologists. The complexity of the pathology is explained by the combined nature of the injuries (often associated with craniofacial injuries), multistage treatments, results that ...
Maria Cervatiuc, Eldor Jonnazarov, Doston Farhodovich Shukuraliev, Mehrob Islomidinovich Yatimov, Abdullo Hudoydodovich Bobobegov, Sukhrobjon Solijonovich Tuychiev, Husan Bahtiyorovich Juraev, Suhrob Tulqinovich Khidiraliev, Makhmudjon Burhonovich Muratov, Sherali Chorshanbeevich Uralov, Dilshod Uralovich Yuldashov, Muslihiddin Ahmadovich Rahimov, Ruslan Usmonjonovich Ghoziev, Idibek Shamsidinovich Mainusov   +13 more
doaj   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Global, regional, and national burden of injuries, and burden attributable to injuries risk factors, 1990 to 2019: results from the Global Burden of Disease study 2019.

OBJECTIVES: In this study, the trends and current situation of the injury burden as well as attributable burden to injury risk factors at global, regional, and national levels based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD)
GBD 2019 Injuries Collaborators,
core   +1 more source

Sports injuries and risk taking behaviours in amateur athletes. [PDF]

, 2012
Research conducted outside of the sports context has shown higher risk for all injuries (e.g., intentional injuries, injured drivers, fatal and non-fatal injuries) among persons with risk-taking behaviors (e.g., cannabis use, alcohol consumption).
Lentillon-Kaestner, Vanessa
core