Results 131 to 140 of about 315,290 (253)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series

Philippine Journal of Ophthalmology, 2019
Objective: To characterize the clinical and pathological features of 4 patients with histopathology-confirmed idiopathic orbital inflammatory disease (OID) initially diagnosed as an orbital neoplasm and 9 patients with histopathology-confirmed orbital ...
Maria Donna Damo Santiago, MD, MBA, Andrei Paolo S. Angbue-Te, MD   +1 more
doaj  

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

Advanced Science, EarlyView.
In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang, Haoxuan Ma, Jichun Guo, Kai Cao, Mengrun Kang, Songling Wang, Fenggang Ren, Yi Lv, Qiang Lu   +17 more
wiley   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Benign Orbit Neoplasm [PDF]

, 2020
openaire   +1 more source

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

Advanced Science, EarlyView.
The C3‐symmetric conjugate TASe, which integrates benzoselenadiazole, alanine, and acylhydrazone modules, self‐assembles into a chalcogen‐/hydrogen‐bonded porous framework in the solid state and uniform chiral nanospheres in aqueous media. These assemblies protect cardiomyocytes from doxorubicin‐induced oxidative injury by scavenging intracellular ...
Jinkui Teng, Renjing Yang, Yu Du, Jingzhong Duan, Yiming Xu, Zhihua He, Guanghui Wang, Wenjing Tian, Aijie Liu, Haifeng Chen, Yun‐Bao Jiang, Xiaosheng Yan   +11 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source