Results 81 to 90 of about 32,454 (260)

Quantum Nanomedicine and Quantum Biomaterials

Advanced Science, EarlyView.
In this perspective, we define quantum nanomedicine and quantum biomaterials as a paradigm that harnesses quantum effects in nanomedicine and biomaterials, including quantum superposition, quantum coherence, quantum tunneling, topological quantum effects, and spin polarization, to achieve either spatiotemporally precise modulation of physiological ...
Xinyue Dai, Liang Chen, Wei Feng, Yu Chen   +3 more
wiley   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Giant Solitary Fibrous Tumour of The Orbit Resected via Subconjunctival Approach

Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi
Solitary fibrous tumours (SFTs) are uncommon neoplasms originating primarily in the pleura but occasionally in the orbit. Despite their generally benign nature, they can exhibit aggressive behaviour.
Mete Zeynal
doaj   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Engineering Nanoemulsions to Maximize NIR‐II Fluorescence and Preserve Photothermal Performance of a Novel Boron Difluoride Formazanate Dye

Angewandte Chemie, EarlyView.
An oil‐in‐water nanoemulsion transforms a boron difluoride formazanate (BDF) dye into a dual‐modal imaging‐guided theranostic agent (BDF‐NE). Its nonpolar oil core maximizes NIR‐II fluorescence while maintaining strong photoacoustic contrast to guide photothermal therapy with high photostability and 66.8% photothermal conversion efficiency, achieving ...
Nahyun Kwon, Francis L. Buguis, Theo Husby, Suhjung Chun, Dongling Zhang, Jiaze Wu, Benjamin Rehl, Binbing Ling, Umar Iqbal, Melissa Washington, Angie Verner, Kai Huang, Juan Chen, Joe B. Gilroy, Gang Zheng   +14 more
wiley   +2 more sources

Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication

BMC Ophthalmology
Objective To comprehensively summarize the clinical and pathological characteristics of primary orbital neoplastic lesions with communication, thereby providing a solid basis for the diagnosis and treatment of such conditions.
Lian Wang, Jing Zhang, Shuo Zhang, Bin Li, Bentao Yang, Hongjuan Liu, Chunli Chen, Qiong Wu, Libin Jiang   +8 more
doaj   +1 more source

Rare Orbital Metastasis of Carcinoid Tumor Despite Long-Term Somatostatin Therapy: A Case Report

Reports
Background and Clinical Significance: Carcinoid tumors are rare, slow-growing neuroendocrine cell neoplasms that typically affect the gastrointestinal tract.
Hritika Hosalkar, Leo Meller, Nahia Dib El Jalbout, Marissa K. Shoji, Sally L. Baxter, Don O. Kikkawa   +5 more
doaj   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source