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Orbitrap mass spectrometry: Instrumentation, ion motion and applications
Mass Spectrometry Reviews, 2008 Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely deliver high resolving power and mass accuracy. Unlike conventional ion traps such as the Paul and Penning traps, the orbitrap uses only electrostatic fields ...
Richard H Perry +2 more
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Coupling liquid chromatography to Orbitrap mass spectrometry [PDF]
Journal of Chromatography A, 2010 The Orbitrap mass analyzer has become a mainstream mass spectrometry technique. In addition to providinga brief introduction to the Orbitrap technology and its continuing development, this article reviewsthe most recent publications quoting the use of the Orbitrap detection for a variety of chromatographicseparation techniques. Its coupling to reversed-
Alexander Alexeyevich Makarov +1 more
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Orbitrap and GC-Orbitrap for in situ analyses: clues from laboratory experiments
2022<p>Introduction</p> <p>The organic molecular diversity present in extraterrestrial bodies such as asteroids and comets is of great interest for understanding the origin of life. However, the onboard analytical techniques are essentially low resolution mass spectrometry which, in view of the molecular diversity,
Adeline Garcia +3 more
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Analytical Chemistry, 2013
Orbitrap is the newest addition to the family of high-resolution mass spectrometry analyzers. With its revolutionarily new, miniature design, Orbitrap combines high speed with excellent quantification properties, ranking favorably in many analytical applications.
Zubarev RA, Makarov A
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Orbitrap is the newest addition to the family of high-resolution mass spectrometry analyzers. With its revolutionarily new, miniature design, Orbitrap combines high speed with excellent quantification properties, ranking favorably in many analytical applications.
Zubarev RA, Makarov A
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The Orbitrap: a new mass spectrometer
Journal of Mass Spectrometry, 2005AbstractResearch areas such as proteomics and metabolomics are driving the demand for mass spectrometers that have high performance but modest power requirements, size, and cost. This paper describes such an instrument, the Orbitrap, based on a new type of mass analyzer invented by Makarov.
Qizhi, Hu +5 more
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Evolution of Orbitrap Mass Spectrometry Instrumentation
Annual Review of Analytical Chemistry, 2015We discuss the evolution of OrbitrapTMmass spectrometry (MS) from its birth in the late 1990s to its current role as one of the most prominent techniques for MS. The Orbitrap mass analyzer is the first high-performance mass analyzer that employs trapping of ions in electrostatic fields.
Shannon, Eliuk, Alexander, Makarov
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High-Throughput Middle-Down Analysis Using an Orbitrap [PDF]
Journal of Proteome Research, 2010 This report demonstrates the application of a capillary LC-LTQ-orbitrap system to provide automated middle-down analysis of proteolytic peptides in the mass range 3000 to 10,000 Da. The novel workflow combines an underutilized method in the orbitrap-high resolution, mass-accurate product ion measurements-with software tailored to search such data ...
Catherine Fenselau, Nathan Edwards
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Orbitrap Mass Analyzer – Overview and Applications in Proteomics
PROTEOMICS, 2006The orbitrap mass analyzer is proving itself as a useful addition to a proteomics tool box. The key attributes of this analyzer are accurate mass and high resolution similar to those achievable with FT ICR instrumentation. The basic principles underlying these capabilities, and how they translate into benefits in real-life proteomics experiments are ...
Michaela, Scigelova, Alexander, Makarov
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Chemical & Engineering News Archive, 2012
Researchers have pushed the limits of the Orbitrap mass analyzer, an instrument with relatively high resolution, to collect mass spectra of intact protein complexes with molecular weights approaching 1 million daltons (Nat. Methods, DOI: 10.1038/nmeth.2208).
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Researchers have pushed the limits of the Orbitrap mass analyzer, an instrument with relatively high resolution, to collect mass spectra of intact protein complexes with molecular weights approaching 1 million daltons (Nat. Methods, DOI: 10.1038/nmeth.2208).
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High-Resolution Characterization of ADCs by Orbitrap LCMS
2019Antibody-drug conjugates (ADCs) have complex molecular structures as they are composed of both small and large molecules, and they often undergo biotransformation over time in circulation. Here we describe a high-resolution Orbitrap MS approach for the characterization of ADC biotransformation and stability. Compared with conventional approach by Q-TOF
Jintang, He, Surinder, Kaur, Keyang, Xu
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