Results 81 to 90 of about 551,491 (329)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

The Orbits of Twisted Crossed Cubes

Mathematics
Two vertices u and v in a graph G=(V,E) are in the same orbit if there exists an automorphism ϕ of G such that ϕ(u)=v. The orbit number of a graph G, denoted by Orb(G), is the number of orbits that partition V(G).
Jia-Jie Liu
doaj   +1 more source

Chaotic orbits in a 3D galactic dynamical model with a double nucleus

, 2012
A 3D-dynamical model is constructed for the study of motion in the central regions of a disk galaxy with a double nucleus. Using the results of the 2D-model, we find the regions of initial conditions in the (x,px,z,py)=EJ, (y=pz=0) phase space producing ...
Caranicolas, Caranicolas, Caranicolas, Cimeno, Debattista, E.E. Zotos, Eracleus, Jalali, Komosca, Lichtenber, Lira, Mast, N.D. Caranicolas, Risality, Samlhus, Soria, Statler, Xinwu   +17 more
core   +1 more source

Nearly horizon skimming orbits of Kerr black holes [PDF]

, 2001
An unusual set of orbits about extreme Kerr black holes resides at the Boyer-Lindquist radius $r = M$, the coordinate of the hole's event horizon. These ``horizon skimming'' orbits have the property that their angular momentum $L_z$ {\it increases} with ...
A. G. Wiseman, A. Ori, C. Lousto, C. W. Misner, D. C. Wilkins, D. Kennefick, F. D. Ryan, F. D. Ryan, F. D. Ryan, J. M. Bardeen, K. S. Thorne, K. S. Thorne, L. Barack, L. M. Burko, L. S. Finn, M. Sasaki, P. C. Peters, P. C. Peters, R. M. Wald, S. A. Hughes, S. A. Hughes, S. A. Teukolsky, S. Sigurdsson, S. Sigurdsson, Scott A. Hughes, T. C. Quinn, Y. Mino   +26 more
core   +2 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

THREE-DIMENSIONAL ANALYSIS OF ORBITAL ANATOMICAL PARAMETERS: A CROSS-SECTIONAL STUDY

Romanian Journal of Oral Rehabilitation
Aim of study. This study aimed to measure orbits to determine asymmetry between the right and left orbit and the gender-specific and age-specific changes to the bony orbit using area, volume, perimeter. Materials and method.
Stefan Gherasimescu, Mihai Liviu Ciofu, Otilia Boişteanu, Daniela Sulea, Petrica-Florin Sava, Vasile-Deniss Mereuta, Ionel Daniel Cojocaru, Victor-Vlad Costan   +7 more
doaj   +1 more source

Lorentz Group and Oriented MICZ-Kepler Orbits

, 2011
The MICZ-Kepler orbits are the non-colliding orbits of the MICZ Kepler problems (the magnetized versions of the Kepler problem). The oriented MICZ-Kepler orbits can be parametrized by the canonical angular momentum $\mathbf L$ and the Lenz vector ...
Meng, Guowu
core   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source