Results 71 to 80 of about 109,132 (281)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Observational Data and Orbits of the Asteroids Discovered at the Molėtai Observatory in 2008–2009

Open Astronomy, 2016
We present the statistics of the asteroids observed and discovered at the Molėtai Observatory, Lithuania, in 2008–2009 within the project for astrometric observations of the near-Earth objects (NEOs), the main belt asteroids and comets.
Černis K., Wlodarczyk I., Zdanavičius J.   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Discovery, Observational Data and the Orbit of the Centaur Asteroid 2012 DS85

Open Astronomy, 2012
A project for astrometric and photometric observations of asteroids at Mt. Graham Observatory with the VATT telescope is described. One of the most important results is a discovery of the Centaur 2012 DS85.
Černis K., Boyle R. P., Laugalys V., Wlodarczyk I.   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Study on the salt-corrosion and oxidation role mechanism of Ni-based single crystal superalloy in the long-term hot corrosion environment

Journal of Materials Research and Technology
Hot corrosion is one of the key factors affecting the long-term service of Ni-based single crystal superalloys. In this paper, the long-term hot corrosion test of a second-generation Ni-based single crystal superalloy was carried out in a high ...
Y.Q. Yang, L. Yang, Y.C. Zhao, H.Q. Pei, Z.X. Wen, Y.C. Zhou   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The potentially hazardous NEA 2001 BB16

Open Astronomy, 2019
We computed the impact solutions of the potentially dangerous Near Earth Asteroid (NEA) 2001 BB16 based on 47 optical observations from January 20.08316 UTC, 2001, through February 09.15740 UTC, 2016, and one radar observation from January 19.90347 UTC ...
Wlodarczyk Ireneusz
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source