Results 71 to 80 of about 112,180 (285)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Observational Data and Orbits of the Asteroids Discovered at the Molėtai Observatory in 2005–2007

Open Astronomy, 2016
The paper presents statistics of the asteroids observed and discovered at the Molėtai Observatory, Lithuania, in 2005–2007 within the project for astrometric observations of the near-Earth objects (NEOs), the main belt asteroids and comets.
Černis K., Wlodarczyk I., Zdanavičius J.   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Observational Data and Orbits of the Asteroids Discovered at the Molėtai Observatory in 2008–2009

Open Astronomy, 2016
We present the statistics of the asteroids observed and discovered at the Molėtai Observatory, Lithuania, in 2008–2009 within the project for astrometric observations of the near-Earth objects (NEOs), the main belt asteroids and comets.
Černis K., Wlodarczyk I., Zdanavičius J.   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Discovery, Observational Data and the Orbit of the Centaur Asteroid 2012 DS85

Open Astronomy, 2012
A project for astrometric and photometric observations of asteroids at Mt. Graham Observatory with the VATT telescope is described. One of the most important results is a discovery of the Centaur 2012 DS85.
Černis K., Boyle R. P., Laugalys V., Wlodarczyk I.   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

New periodic orbits in the solar sail restricted three body problem [PDF]

, 2008
In this paper we consider periodic orbits of a solar sail in the Earth-Sun restricted three-body problem. In particular, we consider orbits which are high above the ecliptic plane, in contrast to the classical Halo orbits about the collinear equilibria ...
Biggs, J.D., Waters, Thomas, McInnes, C.
core   +2 more sources

Study on the salt-corrosion and oxidation role mechanism of Ni-based single crystal superalloy in the long-term hot corrosion environment

Journal of Materials Research and Technology
Hot corrosion is one of the key factors affecting the long-term service of Ni-based single crystal superalloys. In this paper, the long-term hot corrosion test of a second-generation Ni-based single crystal superalloy was carried out in a high ...
Y.Q. Yang, L. Yang, Y.C. Zhao, H.Q. Pei, Z.X. Wen, Y.C. Zhou   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source