Results 221 to 230 of about 128,939 (270)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Exploring an AI-First Healthcare System. [PDF]

Bioengineering (Basel)
Gates A, Ali A, Conard S, Dunn P.
europepmc   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

AI-Augmented Co-Design in Healthcare: Log-Based Markers of Teamwork Behaviors and Collective Intelligence Outcomes. [PDF]

Behav Sci (Basel)
Jiang Y, Chen J, Li Z, Liu L, Clarkson PJ.   +4 more
europepmc   +1 more source

Quantum-entangled neuro-symbolic swarm federation for privacy-preserving IoMT-driven multimodal healthcare. [PDF]

Sci Rep
Ben Othman S, Ali O.
europepmc   +1 more source

Navigating the Complex Landscape of Osteoclastogenesis in Orthodontics. [PDF]

J Bone Metab
Sagar S, Jeyaraj G, Ramani P.
europepmc   +1 more source

Macroscopic quantum effects in the brain: new insights into the fundamental principle underlying conscious processes. [PDF]

Front Hum Neurosci
Keppler J.
europepmc   +1 more source

Architectural patterns for health information systems: a systematic review. [PDF]

Front Digit Health
Casanova R, Villa-Garzon FA, Branch-Bedoya JW.   +2 more
europepmc   +1 more source

A unified AI-driven framework for quantum-secured 6G THz networks with intelligent reflecting surfaces and federated edge learning. [PDF]

Sci Rep
Balaji CG, Menaka S, Rajeswari G, Ponnusamy S.   +3 more
europepmc   +1 more source

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Byrd Orchestrated:

2023
In modern times William Byrd’s music has been repeatedly adapted for orchestral performance, from concise string arrangements to full-throated symphonic renderings. The motivations in crafting these pieces, as well as the ideals underlying the various orchestration techniques, vary significantly across different generations, and so a closer ...
openaire   +1 more source