Results 51 to 60 of about 11,847,542 (311)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Immune-mediated adverse events associated with the checkpoint inhibitor therapy

open access: yesКлинический разбор в общей медицине
Objective: to evaluate immune-related adverse events (irAE) during therapy with immune checkpoint inhibitors. The literary review is based on the analysis of scientific publications hosted on the following databases: CyberLeninka, Web of Science, PubMed,
Vitaly B. Kaliberdenko   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

RETRACTED: Clinical and laboratory substantiation of monarda hydrolate application in complex therapy of mycoses [PDF]

open access: yesBIO Web of Conferences
See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf ...
Prokhorov Dmitry   +6 more
doaj   +1 more source

ORDERED CATEGORIES AND ORDERED SEMIGROUPS [PDF]

open access: yesCommunications in Algebra, 2002
We use ordered categories to study semidirect decompositions of finite ordered semigroups. We obtain ordered analogues of the derived semigroupoid theorem and of the delay theorem. Next we prove that the ordered analogues of semilattices and of J-trivial monoids constitute local varieties, and we derive some decomposition theorems from these results.
Pin, Jean-Eric   +2 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Clinical case of recurrence of Cushing's disease

open access: yesКлинический разбор в общей медицине
This article describes a clinical case of recurrence of Itsenko-Cushing's disease (ICD) in a 22-year-old girl 18 months after endonasal transsphenoidal endoscopic removal of endosellar pituitary adenoma.
Irina N. Repinskaya   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Anticoagulants in modern medical practice

open access: yesКлинический разбор в общей медицине
For a long time, vitamin K antagonists such as warfarin remained the only available means of anticoagulant therapy used for preventive and curative purposes.
Vitaly B. Kaliberdenko   +7 more
doaj   +1 more source

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