Results 81 to 90 of about 24,242,034 (285)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
SPECIFIC FEATURES OF THE IMMUNE STATUS IN NEONATAL PNEUMONIA IN CHILDREN
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018 Background. Pneumonia in newborns is a topical problem of pediatrics because of its significant morbidity, high disability. At present, there is no doubt that the immune system plays a leading role in the pathogenesis, clinical manifestations and ...
Zhuravleva L. N., Novikova V. I.
doaj +1 more source
Pricing Mortgages: An Interpretation of the Models and Results [PDF]
Mortgages, like all debt securities, can be viewed as risk-free assets plus or minus contingent claims that can be usefully viewed as options. The most important options are: prepayment, which is a call option giving the borrower the right to buy back ...
Patric H. Hendershott, Robert Van Order
core
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
A review of endocrine therapy for hormone-dependent breast cancer
Сибирский онкологический журналPurpose of the study: to provide current data on pharmacotherapy of hormone-dependent breast cancer (hdBC) and to consider the feasibility of introducing new hormone therapy drugs for breast cancer into clinical practice. Material and Methods.
A. N. Useinova +4 more
doaj +1 more source
Ordered chaining for total orderings [PDF]
, 1994 We design new inference systems for total orderings by applying rewrite techniques to chaining calculi. Equality relations may either be specified axiomatically or built into the deductive calculus via paramodulation or superposition. We demonstrate that our inference systems are compatible with a concept of (global) redundancy for clauses and ...
Bachmair, L., Ganzinger, H.
openaire +3 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
MEDICINAL SUCCULENT PLANTS IN THE COLLECTION OF THE NIKITA BOTANICAL GARDEN
Овощи России, 2019 Succulent plants are of a special interest for Russian botanical gardens’ collections, many of them are meant to be used not only in phytodesign but in pharmacy while drug manufacturing.
E. S. Chichkanova +3 more
doaj +1 more source