Results 111 to 120 of about 1,606,254 (293)

Portfolio Allocation and Alternative Structures of the Standard Reinsurance Agreement [PDF]

open access: yes
This paper examines how insurance companies participating in delivery of crop insurance would change patterns of portfolio allocation across reinsurance funds in reaction to the 2005 Standard Reinsurance Agreement.
Dismukes, Robert   +3 more
core   +1 more source

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

open access: yesAdvanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang   +7 more
wiley   +1 more source

Sequential communication with ex post participation constraints [PDF]

open access: yes
The paper examines the implementation of Bayesian allocation rules that satisfy non-negative ex post payoffs for one player in a two-players bilateral asymmetric information setting.
Ambec, S.
core  

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

open access: yesAdvanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen   +14 more
wiley   +1 more source

Supplier Selection and Order Allocation in A Pharmaceutical Wholesaler

open access: yesJurnal Teknik Industri
Supplier selection is essential for any organization , as it plays a significant role in enhancing productivity. This study focuses on a local pharmaceutical wholesaler (PW) company, which places orders with other local PWs to meet its demand. Typically,
Ryan Hikmah Fadilla   +2 more
doaj   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

open access: yesAdvanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño   +5 more
wiley   +1 more source

A Permit Allocation Contest for a Tradable Pollution Permit Market [PDF]

open access: yes
In this paper we advocate a new initial allocation mechanism for a tradable pollution permit market. We outline a Permit Allocation Contest (PAC) that distributes permits to firms based on their rank relative to other firms.
Ian A. MacKenzie,   +2 more
core  

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

open access: yesAdvanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen   +7 more
wiley   +1 more source

Integrated economic-hydrologic water modeling at the basin scale: the Maipo river basin [PDF]

open access: yes
Increasing competition for water across sectors increases the importance of the river basin as the appropriate unit of analysis to address the challenges facing water resources management; and modeling at this scale can provide essential information for ...
Cai, Ximing   +5 more
core  

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