Results 61 to 70 of about 1,260 (246)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A data-driven picking strategy for micro fulfilment centers in quick commerce: the case of Korea

Transport
Quick Commerce (Q-Commerce) allows customers to receive their orders from near Micro Fulfilment Centers (MFCs) in a short time. However, the fulfilment centers are difficult to maintain responsive and reliable delivery services with traditional Single ...
Kwang-Tae Kim, Dong-Hoon Son, Hyunwoo Kim, Hongchul Lee   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Research on order batching optimization based on improved NSGA-II algorithm.

PLoS ONE
In the context of e-commerce, the order batching optimization problem in e-commerce warehousing centers has been addressed by establishing a model aimed at minimizing the order picking time, order delay costs, and picking costs, as well as achieving ...
Huiyue Xu, Juping Shao, Yanan Sun
doaj   +1 more source

An adaptive agent-based approach for instant delivery order dispatching: Incorporating task buffering and dynamic batching strategies

International Journal of Transportation Science and Technology
The volume of instant delivery has witnessed a significant growth in recent years. Given the involvement of numerous heterogeneous stakeholders, instant delivery operations are inherently characterized by dynamics and uncertainties. This study introduces
Miaojia Lu, Xinyu Yan, Shadi Sharif Azadeh, Pengling Wang   +3 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Tabu search heuristics for the order batching problem in manual order picking systems [PDF]

European Journal of Operational Research, 2012
Working papers series, ISSN 2628-1724, 2010, Heft ...
Sebastian Henn, Gerhard Wäscher
openaire   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Multi-formalism Models for Performance Engineering

Future Internet, 2020
Nowadays, the necessity to predict the performance of cloud and edge computing-based architectures has become paramount, in order to respond to the pressure of data growth and more aggressive level of service agreements.
Enrico Barbierato, Marco Gribaudo, Giuseppe Serazzi   +2 more
doaj   +1 more source