Results 51 to 60 of about 576,963 (265)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Influence of the Order Exchange of the Node Connection in the Force Analysis of Steel Structures

Frontiers in Materials, 2022
In the mechanical analysis of steel structures, whether it is static analysis or dynamic analysis, it is necessary to establish the structural stiffness matrix first.
Shuai Luo, Dehai Song, Kangli Shen, Rui Fang, Wei Wang   +4 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Exchange Rate Fundamentals and Order Flow [PDF]

Quarterly Journal of Finance, 2012
We address whether transaction flows in foreign exchange markets convey fundamental information. Our General Equilibrium model includes fundamental information that first manifests at the micro level and is not symmetrically observed by all agents.
Martin D. D. Evans, Richard K. Lyons
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Identification of Effective Factors on Real Exchange Rate Misalignment and Its Impact on Economic Growth in Iran [PDF]

Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2009
The purpose of this survey is to determine of equilibrium real exchange rate, misalignment and impact of misalignment of real exchange rate on economic growth.
Manoochehr Asgari, Hamid Tofighi
doaj  

Spatial and temporal variation in river corridor exchange across a 5th-order mountain stream network [PDF]

Hydrology and Earth System Sciences, 2019
Although most field and modeling studies of river corridor exchange have been conducted at scales ranging from tens to hundreds of meters, results of these studies are used to predict their ecological and hydrological influences at the scale of river ...
A. S. Ward, S. M. Wondzell, N. M. Schmadel, N. M. Schmadel, S. Herzog, J. P. Zarnetske, V. Baranov, V. Baranov, P. J. Blaen, P. J. Blaen, P. J. Blaen, N. Brekenfeld, R. Chu, R. Derelle, J. Drummond, J. Drummond, J. H. Fleckenstein, J. H. Fleckenstein, V. Garayburu-Caruso, E. Graham, D. Hannah, C. J. Harman, J. Hixson, J. L. A. Knapp, J. L. A. Knapp, S. Krause, M. J. Kurz, M. J. Kurz, J. Lewandowski, J. Lewandowski, A. Li, E. Martí, M. Miller, A. M. Milner, K. Neil, L. Orsini, A. I. Packman, S. Plont, S. Plont, L. Renteria, K. Roche, T. Royer, C. Segura, J. Stegen, J. Toyoda, J. Wells, N. I. Wisnoski   +46 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source