Results 91 to 100 of about 13,288,132 (297)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Design of Two-phase Slug Flow Microreactors Using Reduced Order Flow Model

Chemical Engineering Transactions
Two-phase slug flow microreactors (SFMRs) are known to be capable of achieving more efficient mass and heat transfer than conventional reactors. However, no method for designing SFMRs has been established so far.
Takaki Yamazaki, Keisuke Miyabayashi, Osamu Tonomura   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Coming Multi-Order World [PDF]

, 2016
The article shows that the current international system is changing towards a completely new form of international system, conceptualized as a multi-order system. The suggestion for a multi-order world stands in contrast to three current narratives about
Flockhart, Trine
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Fixed versus Flexible: Lessons from EMS Order Flow [PDF]

This paper addresses the puzzle of regime-dependent volatility in foreign exchange. We extend the literature in two ways. First, our microstructural model provides a qualitatively new explanation for the puzzle.
William P. Killeen, Richard K. Lyons, Michael J. Moore   +2 more
core  

Component parts of the World Heat Flow Data Collection

, 2013
This data set is a compilation of heat flow data of uncertain origin. References as cited in Global Heat Flow Database were incomplete and thus could not be verified.
Global Heat Flow Compilation Group, Global Heat Flow Compilation Group (8004602)   +1 more
core   +1 more source

How To Use Flow 3XL

, 2020
Flow 3XL Ginseng - Ginseng is herb that really you along with stress. I'd say that about 50 % the people on ginseng actually experience results. It comes in tons of forms like, Indian, American, Korean, and Siberian ginseng.
Flow 3XL
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The dynamic interaction of order flows and the CAD/USD exchange rate [PDF]

We explore the relationship between disaggregated order flow, the Canada/U.S. dollar (CAD/USD) market and U.S. macroeconomic announcements. Three types of CAD order flow and the CAD/USD are cointegrated.
Christopher J. Neely, Nikola Gradojevic
core