Results 91 to 100 of about 3,457,111 (263)
Upper and lower bounds for first order expressibility
Journal of Computer and System Sciences, 1980 AbstractWe study first order expressibility as a measure of complexity. We introduce the new class Var&Sz[v(n),z(n)] of languages expressible by a uniform sequence of sentences with v(n) variables and size O[z(n)]. When v(n) is constant our uniformity condition is syntactical and thus the following characterizations of P and PSPACE come entirely from ...
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On Exponential Lower Bounds for Partially Ordered Resolution
Journal on Satisfiability, Boolean Modeling and Computation, 2016 Is well-known that the proof size in propositional resolution is sensitive to the order of how variables are resolved on. Indeed, imposing a certain resolution order can lead to an exponential blowup compared to unrestricted resolution. In this paper we study even a weaker restriction.
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Interaction of Lower and Higher Order Hamiltonian Resonances
International Journal of Bifurcation and Chaos, 2018 The tools of normal forms and recurrence are used to analyze the interaction of low and higher order resonances in Hamiltonian systems. The resonance zones where the short-periodic solutions of the low order resonances exist are characterized by small variations of the corresponding actions that match the variations of the higher order resonance; this
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Elimination of pulse-noise from mixed-noise based on fractional lower order ICA
Tongxin xuebao, 2011 In order to solve the problem that traditional denoising methods based on the second order statistics were usually degraded in their performance when the received signal was contaminated by both Gaussian and Alpha stable noises.A fractional lower order ...
QIU Tian-shuang1 +2 more
doaj +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source