Results 51 to 60 of about 665,321 (256)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Learning Discriminative Appearance Models for Online Multi-Object Tracking With Appearance Discriminability Measures

IEEE Access, 2018
A data association, which links detections in consecutive frames, is a key issue in multi-object tracking (MOT). For robust data association in a complex scene, a common approach is to learn object appearance models for handling appearance variations of ...
Seong-Ho Lee, Myung-Yun Kim, Seung-Hwan Bae   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A red Fuji apple appearance grading method based on improved whale optimization algorithm and CNN

Shipin yu jixie
Objective: In order to improve the accuracy of machine vision technology in grading the appearance quality of red Fuji apples, a red Fuji apple appearance grading method based on improved whale optimization algorithm （WOA） and CNN is proposed. Methods: A
LIU Sujiao, LU Mingxing, WANG Chunfang, ZHAO Zifeng, LIU Yi   +4 more
doaj   +1 more source

Foreground Extraction Combining Graph Cut and Histogram Shape Analysis

IEEE Access, 2019
This paper presents a foreground extraction model which develops the Grab Cut model by applying the histogram shape analysis method. In this model, the foreground extraction is formulated as an inference problem based on edges and appearance models.
Kun He, Dan Wang, Bin Wang, Ben Feng, Chenyu Li   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Robust Visual Tracking via Patch Descriptor and Structural Local Sparse Representation

Algorithms, 2018
Appearance models play an important role in visual tracking. Effective modeling of the appearance of tracked objects is still a challenging problem because of object appearance changes caused by factors, such as partial occlusion, illumination variation ...
Zhiguo Song, Jifeng Sun, Jialin Yu, Shengqing Liu   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source