Results 101 to 110 of about 1,086,807 (332)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Simulated performance of an order statistic threshold strategy for detection of narrowband signals [PDF]

open access: yes
The application of order statistics to signal detection is becoming an increasingly active area of research. This is due to the inherent robustness of rank estimators in the presence of large outliers that would significantly degrade more conventional ...
Brady, R.   +4 more
core   +1 more source

Kumaraswamy-Half-Cauchy Distribution: Characterizations and Related Results [PDF]

open access: yes, 2015
We present various characterizations of a recently introduced distribution (Ghosh 2014), called Kumaraswamy- Half- Cauchy distribution based on: (i) a simple relation between two truncated moments; (ii) truncated moment of certain function of the 1st ...
Ghosh, I., Hamedani, Gholamhossein
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Sequential order statistics with an order statistics prior

open access: yesJournal of Multivariate Analysis, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kateri, M., Burkschat, M., Kamps, U.
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Problems of Upgrading Statistic Estimation of Non-Observed Economy in Uzbekistan

open access: yesВестник Российского экономического университета имени Г. В. Плеханова
The goal of the article is to find key trends in upgrading statistic estimation of non-observed economy in the Republic of Uzbekistan by using international experience, digital technologies, analytical and statistic methods.
B. A. Begalov, I. E. Zhukovskaya
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

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