Results 111 to 120 of about 270,694 (310)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Indirect likelihood inference [PDF]
Given a sample from a fully specified parametric model, let Zn be a given finite-dimensional statistic - for example, an initial estimator or a set of sample moments. We propose to (re-)estimate the parameters of the model by maximizing the likelihood of
Michael Creel, Dennis Kristensen
core
Document processing for adaptive page segmentation using order statistic filters [PDF]
, 2001 Page segmentation is one of the important and basic research subjects of document analysis. Traditionally, there are two major kinds of page segmentation approaches. One is the top-down approach and the other is the bottom-up approach.
Ma, Li, 1975-
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Second-order approximation for adaptive regression estimators. [PDF]
We derive asymptotic expansions for semiparametric adaptive regression estimators. In particular, we derive the asymptotic distribution of the second-order effect of an adaptive estimator in a linear regression whose error density is of unknown ...
Linton, Oliver, Xiao, Zhijie
core +1 more source
A statistic on involutions [PDF]
, 2001 We define a statistic, called weight, on involutions and consider two applications in which this statistic arises. Let I(n) denote the set of all involutions on [n](={1,2,..., n}) and let F(2n) denote the set of all fixed point free involutions on [2n ...
SRINIVASAN, MK, DEODHAR, RS
core +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Problems of Upgrading Statistic Estimation of Non-Observed Economy in Uzbekistan
Вестник Российского экономического университета имени Г. В. ПлехановаThe goal of the article is to find key trends in upgrading statistic estimation of non-observed economy in the Republic of Uzbekistan by using international experience, digital technologies, analytical and statistic methods.
B. A. Begalov, I. E. Zhukovskaya
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source