Results 81 to 90 of about 1,229,548 (261)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

The Distribution of Order Statistics Under Sampling Without Replacement

open access: yesJournal of Statistical Theory and Applications (JSTA)
This paper examines the distribution of order statistics taken from simple-random-sampling without replacement (SRSWOR) from a finite population with values $$1,\dots ,N$$ 1 , ⋯ , N .
B. O’Neill
doaj   +1 more source

On order statistics from the Gompertz–Makeham distribution and the Lambert W function

open access: yesMathematical Modelling and Analysis, 2013
The aim of this paper is twofold. First, we show that the expected value of the minimum order statistic from the Gompertz-Makeham distribution can be expressed in closed form in terms of the incomplete gamma function.
Pedro Jodra
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Some Information Properties of Order Statistics of Skew-normal Distribution

open access: yesRevstat Statistical Journal
The skew-normal distribution and some of its extensions have been considered in the last two decades in view of distribution theory and the associated properties. However, less attention has been paid to other aspects of this family of distributions. In
Parisa Hasanalipour   +2 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

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