Results 61 to 70 of about 1,229,548 (261)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Using Order Texture Statistics to Classify Multi-Class Malware

open access: yesScientific Journal of King Faisal University: Basic and Applied Sciences
The most significant challenge in the security of information and communication networks is the escalating number of malware types, followed by the search for appropriate methods to protect systems against them, which is one of the most critical concerns
Raaed Fadhil Mohammed
doaj   +1 more source

On the Muth Distribution

open access: yesMathematical Modelling and Analysis, 2015
The Muth distribution is a continuous random variable introduced in the context of reliability theory. In this paper, some mathematical properties of the model are derived, including analytical expressions for the moment generating function, moments ...
Pedro Jodra   +2 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Towards an application of fourth-order shear statistics

open access: yesAstronomy & Astrophysics
Context. Higher-order shear statistics contain part of the non-Gaussian information of the projected matter field and can therefore provide additional constraints on the cosmological parameters when combined with second-order statistics. Aims.
Silvestre-Rosello Elena   +6 more
doaj   +1 more source

Complete convergence for arrays of ratios of order statistics

open access: yesOpen Mathematics, 2019
Let {Xn,k, 1 ≤ k ≤ mn, n ≥ 1} be an array of independent random variables from the Pareto distribution. Let Xn(k) be the kth largest order statistic from the nth row of the array and set Rn,in,jn = Xn(jn)/Xn(in) where jn < in. The aim of this paper is to
Miao Yu   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Exact distributions of order statistics from ln,p-symmetric sample distributions

open access: yesDependence Modeling, 2017
We derive the exact distributions of order statistics from a finite number of, in general, dependent random variables following a joint ln,p-symmetric distribution. To this end,we first review the special cases of order statistics fromspherical aswell as
Müller K., Richter W.-D.
doaj   +1 more source

The Inverted Exponentiated Gamma Distribution: A Heavy-Tailed Model with Upside Down Bathtub Shaped Hazard Rate

open access: yesStatistica, 2019
In this article, we proposed and studied the inverted exponentiated gamma distribution (IEGD). IEGD is obtained by considering the inverse transformation of exponentiated gamma variate.
Abhimanyu Singh Yadav
doaj   +1 more source

The Odds Generalized Gamma-G Family of Distributions: Properties, Regressions and Applications

open access: yesStatistica, 2020
In this article, a new "odds generalized gamma-G" family of distributions, called the GG-G family of distributions, is introduced. We propose a complete mathematical and statistical study of this family, with a special focus on the Fréchet distribution ...
M. Arslan Nasir   +4 more
doaj   +1 more source

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