Results 61 to 70 of about 11,862,847 (308)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Distributional Results for Dependent Type-II Hybrid Censored Order Statistics [PDF]

, 2017
The scheme of type-II hybrid censoring is of great value in life-testing experiments. In the literature, type-II hybrid censored order statistics are assumed to arise from independent random variables.
Hamid Dashti, Dashti, Hamid, Pak, Abbas, Abbas Pak   +3 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

2021-2022 AAAL Statistics

, 2023
Annual institutional statistics collection for AAAL member libraries.
Statistics, AAAL
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Fuzzy Improved Distributions for Exceedance Counts in Order Statistic Intervals

Mathematics
We study exceedance counts for order statistic intervals when boundary uncertainty is modeled through a fuzzy improved distribution function. In an ordinary setting, whether an observation falls below a threshold is decided by a crisp comparison, which ...
Gulser Oz, Ismihan Bayramoglu
doaj   +1 more source

Generalized Order Statistics from Marshall–Olkin Extended Exponential Distribution

Journal of Statistical Theory and Applications (JSTA), 2019
A.W. Marshall, I. Olkin, Biometrika. 84 (1997), 641–652, introduced an interesting method of adding a new parameter to an existing distribution. The resulting new distribution is called as Marshall–Olkin extended distribution.
Haseeb Athar, Nayabuddin, Saima Zarrin
doaj   +1 more source

Order Statistics and Statistics of Structure $(d)$

The Annals of Mathematical Statistics, 1965
This note discusses the asymptotic independence of the "$(d)$-structured" order statistics $F(X^{(i)})$ and some of the more usual statistics of structure $(d)$. (For a discussion of structure $(d)$ and related concepts, see references [2], [3] and [4].) Asymptotic independence holds, in particular, in the case of the Kolmogoroff-Smirnoff statistic ...
openaire   +2 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source