Results 51 to 60 of about 32,028 (266)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Systems of Inequalities Characterizing Ring Homomorphisms
Journal of Function Spaces, 2016 Assume that T:P→R and U:P→R are arbitrary mappings between two partially ordered rings P and R. We study a few systems of functional inequalities which characterize ring homomorphisms.
Włodzimierz Fechner, Andrzej Olbryś
doaj +1 more source
Crystal structure of catena-poly[[aquabis(4-formylbenzoato)-κ2O1,O1′;κO1-zinc]-μ-pyrazine-κ2N:N′]
Acta Crystallographica Section E: Crystallographic Communications, 2015 The asymmetric unit of the title polymeric compound, [Zn(C8H5O3)2(C4H4N2)(H2O)]n, contains two molecular units. Each unit comprises two 4-formylbenzoate (FB) anions, one pyrazine molecule and one coordinating water molecule; the FB anions act either as ...
Gülçin Şefiye Aşkın +4 more
doaj +1 more source
The Witt ring of a space of orderings [PDF]
Transactions of the American Mathematical Society, 1980 The theory of “space of orderings” generalizes the reduced theory of quadratic forms over fields (or, more generally, over semilocal rings). The category of spaces of orderings is equivalent to a certain category of “abstract Witt rings".
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Acta Crystallographica Section E, 2012 The title co-crystal, [Eu(NCS)3(C18H15OP)3][Eu(NCS)2(NO3)(C18H15OP)3], contains two distinct neutral complexes. Each complex has threefold symmetry about its central Eu3+ ion.
Anthony T. Thames +4 more
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Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures
Frontiers in Chemistry, 2020 Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades.
Wenbo Zhang +5 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source