Results 81 to 90 of about 28,313 (214)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

THE POSSIBLE ORDERED STRUCTURES OF ICE Ih

open access: yes, 1987
En considérant la récente découverte de la glace XI, la forme ordonnée de la glace Ih, il est intéressant d'étudier les possibilités d'arrangement protoniques dans cette phase Ih.
R. HOWE
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

On the Riesz structures of a lattice ordered abelian group

open access: yes, 2019
A Riesz structure on a lattice ordered abelian group G is a real vector space structure where the product of a positive element of G and a positive real is positive. In this paper we show that for every cardinal k there is a totally ordered abelian group
Lenzi, Giacomo
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Bipolarization of posets and natural interpolation [PDF]

open access: yes
The Choquet integral w.r.t. a capacity can be seen in the finite case as a parsimonious linear interpolator between vertices of $[0,1]^n$. We take this basic fact as a starting point to define the Choquet integral in a very general way, using the ...
Michel Grabisch, Christophe Labreuche
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Definable sets in ordered structures. I

open access: yes, 1986
This paper introduces and begins the study of a well-behaved class of linearly ordered structures, the O \mathcal {O} -minimal structures. The definition of this class and the corresponding class of theories, the strongly
Anand Pillay, Charles Steinhorn
core   +1 more source

Order And Structure In Syntax I: Word Order And Syntactic Structure

open access: yes, 2017
This book reconsiders the role of order and structure in syntax, focusing on fundamental issues such as word order and grammatical functions. The papers in the collection ask what word order can tell us about syntactic structure, using evidence from V2, object shift, word order gaps and different kinds of movement. All of the papers address in some way
Laura R. Bailey, Michelle Sheehan
openaire   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

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