Results 41 to 50 of about 305,204 (290)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Generalized quasiconvex set-valued maps

Journal of Numerical Analysis and Approximation Theory, 2002
The aim of this paper is to introduce a concept of quasiconvexity for set-valued maps in a general framework, by only considering an abstract convexity structure in the domain and an arbitrary binary relation in the codomain.
Nicolae Popovici
doaj   +2 more sources

Reduced Dilation-Erosion Perceptron for Binary Classification

Mathematics, 2020
Dilation and erosion are two elementary operations from mathematical morphology, a non-linear lattice computing methodology widely used for image processing and analysis. The dilation-erosion perceptron (DEP) is a morphological neural network obtained by
Marcos Eduardo Valle
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Fault Detection and Diagnosis in Process Data Using Support Vector Machines

Journal of Applied Mathematics, 2014
For the complex industrial process, it has become increasingly challenging to effectively diagnose complicated faults. In this paper, a combined measure of the original Support Vector Machine (SVM) and Principal Component Analysis (PCA) is provided to ...
Fang Wu, Shen Yin, Hamid Reza Karimi
doaj   +1 more source

Some critical remarks on the paper “A note on the metrizability of tvs-cone metric spaces” / Некоторые критические замечания о работе «Заметки о метризуемости твп-конических пространств» / Neke kritičke napomene o radu “Beleška o metrizabilnosti tvp-konusnih metričkih prostora” [PDF]

Vojnotehnički Glasnik, 2018
This short and concise note provides a detailed exposition of the approach and results established by (Lin et al, 2015, pp.271-279). We show that the obtained results are not particularly surprising and new.
Suzana M. Aleksić, Ljiljana R. Paunović, Stojan N. Radenović, Francesca Vetro   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Post-processing of Deep Web Information Extraction Based on Domain Ontology

Advances in Electrical and Computer Engineering, 2013
Many methods are utilized to extract and process query results in deep Web, which rely on the different structures of Web pages and various designing modes of databases. However, some semantic meanings and relations are ignored.
PENG, T., LIU, L.
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Bands in partially ordered vector spaces with order unit [PDF]

, 2014
In an Archimedean directed partially ordered vector space X, one can define the concept of a band in terms of disjointness. Bands can be studied by using a vector lattice cover Y of X.
A. Kalauch, Bas Lemmens, O. Gaans
semanticscholar   +1 more source