Results 101 to 110 of about 320,000 (291)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Labour Turnover and Firm Performance [PDF]

, 2007
We explore the impact of labour turnover on firm performance by analysing the predictions of an extension of the efficiency wage model of Salop (1979) developed by Garino and Martin (2007), which separates incumbent and newly hired workers in the ...
Brown, S., Garino, G., Martin, C.
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Data-driven sustainable supply chain management with MEREC-EDAS approach using bipolar fuzzy credibility numbers

Alexandria Engineering Journal
This paper presents the novel concept of bipolar fuzzy credibility numbers (BFCNs) which is a robust extension of bipolar fuzzy numbers (BFNs). The BFCNs integrate credibility measures to effectively manage bipolarity and vagueness.
Muhammad Riaz, Nabiah Mazher, Asia Tahir, Muhammad Aslam, Dragan Pamucar, Vladimir Simic   +5 more
doaj   +1 more source

Effects of chemical composition and B2 order on phonons in bcc Fe–Co alloys [PDF]

, 2010
The phonon density of states (DOS) gives insight into interatomic forces and provides the vibrational entropy, making it a key thermodynamic function for understanding alloy phase transformations. Nuclear resonant inelastic x-ray scattering and inelastic
Abernathy, D. L., Delaire, O., Fultz, B., Horwath, J., Li, Chen W., Lucas, M. S., Mauger, L., Muñoz, J. A., Sheets, A. O., Stone, M. B., Turgut, Z., Xiao, Yuming   +11 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Multi attribute group decision-making based on quasirung orthopair fuzzy Frank aggregation operators for optimal vehicle selection

Scientific Reports
This study proposes novel operational laws that extend the Frank t-norm and t-conorm to develop a new class of aggregation operators (AOs), namely the $$p,q-$$ quasirung orthopair fuzzy Frank weighted average, weighted geometric, ordered weighted average,
Salma Khan, Hamza Ali Abujabal, Muhammad Rahim, A. Almutairi, Alhanouf Alburaikan, Hamiden Abd El-Wahed Khalifa   +5 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Ecological Risk Assessment of Watersheds Based on Adaptive Cycling Theory—A Case Study of Poyang Lake Ecological and Economic Zone

Land
Under the global urbanization context, irrational land use patterns have exacerbated ecosystem imbalance. Developing watershed ecological risk assessment methods based on adaptive cycle theory holds significant scientific importance for flood risk ...
Yixi Gu, Jiaxuan Wang, Xinyi Su, Kaili Zhang   +3 more
doaj   +1 more source