Results 71 to 80 of about 94,544 (296)

MODEL PENILAIAN ASPEK AFEKTIF ‘AKHLAK MULIA’ BERBASIS DATA LINGUISTIK [PDF]

, 2012
Penilaian aspek afektif di sekolah merupakan proses pengambilan keputusan yang harus memperhitungkan banyak kriteria. Selain itu, penilaian aspek afektif juga dapat dipandang sebagai suatu pengambilan keputusan kelompok oleh beberapa orang guru, dengan ...
Sri, Andayani
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The prioritization of solutions for reducing the influence of climate change on the environment by using the conception of bipolar complex fuzzy power Dombi aggregation operators

Frontiers in Environmental Science, 2023
This article aims to examine the causes and consequences of climate change on the environment and then prioritize the solution for reducing its influence on the environment under the setting of the bipolar complex fuzzy set (BCFS).
Tahir Mahmood, Ubaid Ur Rehman, Gustavo Santos-García   +2 more
doaj   +1 more source

Using fuzzy numbers and OWA operators in the weighted average and its application in decision making [PDF]

, 2009
Se presenta un nuevo método para tratar situaciones de incertidumbre en los que se utiliza el operador OWAWA (media ponderada – media ponderada ordenada). A este operador se le denomina operador OWAWA borroso (FOWAWA).
Casanovas Ramón, Montserrat, Cossío Silva, Francisco José (Coordinador), Merigó Lindahl, José M.   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Generalized Hybrid Averaging Operator and its Application in Decision Making // La media generalizada híbrida y su aplicación en la toma de decisiones [PDF]

Revista de Métodos Cuantitativos para la Economía y la Empresa, 2010
We present the generalized hybrid averaging (GHA) operator. It is a new aggregation operator that generalizes the hybrid averaging (HA) operator by using the generalized mean. Thus, we are able to generalize a wide range of mean operators such as the HA,
Casanovas Ramón, Montserrat, Merigó Lindahl, José M.   +1 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Systems with Symmetry Breaking and Restoration

, 2010
Statistical systems, in which spontaneous symmetry breaking can be accompanied by spontaneous local symmetry restoration, are considered. A general approach to describing such systems is formulated, based on the notion of weighted Hilbert spaces and ...
Yukalov, V. I.
core   +2 more sources