Results 41 to 50 of about 483,652 (264)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Against Negativism: Why Critical Theory Should Appeal to the Good

open access: yesPolitical Philosophy
In this article, I argue against negativism in critical theory. Negativism holds that critical theory should avoid appealing to explicit positive normative standards (“the good”) in its social critique.
Luca Hemmerich
doaj   +2 more sources

Órdenes y beneficios en Palencia

open access: yesEspacio, Tiempo y Forma. Serie V, Historia Contemporánea, 2001
Se analiza en primer lugar los diferentes tipos de órdenes sagradas existentes en el seno de la Iglesia, así como los requisitos para acceder a cada una.
Almudena García Herreros
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Algorithms of capacity planning and production scheduling prognosis creation a capacity balance of Alfa Foils, a.s. planning system [PDF]

open access: yesActa Montanistica Slovaca, 2008
Firm forecasting and planning base on operative approach bears only measure of request production saturation. After overload“point of bearing” occur collapse planning system, i.e.
Zuzana Marková   +2 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

ORDERED CATEGORIES AND ORDERED SEMIGROUPS [PDF]

open access: yesCommunications in Algebra, 2002
We use ordered categories to study semidirect decompositions of finite ordered semigroups. We obtain ordered analogues of the derived semigroupoid theorem and of the delay theorem. Next we prove that the ordered analogues of semilattices and of J-trivial monoids constitute local varieties, and we derive some decomposition theorems from these results.
Pin, Jean-Eric   +2 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

TRIAL BY JURY AS A GUARANTEE OF LEGITIMATE DECISIONS: CONSTITUTIONAL, LEGAL AND ECONOMIC PRINCIPLES

open access: yesBaltic Journal of Economic Studies
The article is devoted to the analysis of the constitutional, legal and economic foundations of the jury trial as a guarantee of legal decision-making. The issue of jury trial remains extremely relevant in the context of building a democratic society and
Veronika Berch   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy