Results 51 to 60 of about 391,016 (273)
On Nonlinear Dynamics of the STAT5a Signaling Protein
Biomath, 2014 In this paper we model the dynamics of the cross talk between MEK/ERK and JAK/STAT signaling pathways by means of nonlinear ordinary differential equations.
Elena Nikolova +2 more
doaj +1 more source
Motion Planning of Uncertain Ordinary Differential Equation Systems [PDF]
, 2011 This work presents a novel motion planning framework, rooted in nonlinear programming theory, that treats uncertain fully and under-actuated dynamical systems described by ordinary differential equations.
Hays, Joe +3 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Population Growth Models Using Fuzzy Ordinary Differential Equation
Semina: Ciências Exatas e TecnológicasFuzzy mathematics is a branch of mathematics that presents a new approach to the classical notion of set, enabling the generalization of concepts and results from classical mathematics.
Diogo Sampaio da Silva +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Doubly Periodic Meromorphic Solutions of Autonomous Nonlinear Differential Equations
Моделирование и анализ информационных систем, 2014 The problem of constructing and classifying elliptic solutions of nonlinear differential equations is studied. An effective method enabling one to find an elliptic solution of an autonomous nonlinear ordinary differential equation is described.
M. V. Demina, N. A. Kudryashov
doaj +1 more source
Numerical Solution of Stieltjes Differential Equations
Mathematics, 2020 This work is devoted to the obtaining of a new numerical scheme based on quadrature formulae for the Lebesgue–Stieltjes integral for the approximation of Stieltjes ordinary differential equations.
Francisco J. Fernández +1 more
doaj +1 more source
Four Steps Implicit Method for the Solution of General Second Order Ordinary Differential Equations [PDF]
, 2009 Four steps implicit scheme for the solution of second order ordinary differential equation was derived through interpolation and collocation method. Newton polynomial approximation method was used to generate the unknown parameters in the corrector ...
Adesanya, A.O. +3 more
core
Ermakov-Pinney and Emden-Fowler equations: new solutions from novel B\"acklund transformations
, 2017 The class of nonlinear ordinary differential equations $y^{\prime\prime}y = F(z,y^2)$, where F is a smooth function, is studied. Various nonlinear ordinary differential equations, whose applicative importance is well known, belong to such a class of ...
Carillo, Sandra, Zullo, Federico
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source